HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Pei Chen Hsu; Chao Chun Chen; Huey En Tzeng; Yuan Nian Hsu; Chien Chung Kuo; Meng Liang Lin; Wen Shin Chang; Yun Chi Wang; Chia Wen Tsai; Jen Sheng Pei; DA Tian Bau

doi:10.21873/invivo.11576

HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Pei Chen Hsu, Chao Chun Chen, Huey En Tzeng, Yuan Nian Hsu, Chien Chung Kuo, Meng Liang Lin, Wen Shin Chang, Yun Chi Wang, Chia Wen Tsai, Jen Sheng Pei, DA Tian Bau

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

Original language	English
Pages (from-to)	1081-1086
Number of pages	6
Journal	In vivo (Athens, Greece)
Volume	33
Issue number	4
DOIs	https://doi.org/10.21873/invivo.11576
Publication status	Published - Jul 1 2019

Keywords

Childhood leukemia
genotype
hOGG1
polymorphism
Taiwan

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/invivo.11576

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HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population. / Hsu, Pei Chen; Chen, Chao Chun; Tzeng, Huey En; Hsu, Yuan Nian; Kuo, Chien Chung; Lin, Meng Liang; Chang, Wen Shin; Wang, Yun Chi; Tsai, Chia Wen; Pei, Jen Sheng; Bau, DA Tian.

In: In vivo (Athens, Greece), Vol. 33, No. 4, 01.07.2019, p. 1081-1086.

Research output: Contribution to journal › Article › peer-review

@article{a8372eca6aad4ce59023272f1e341c34,

title = "HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population",

abstract = "BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.",

keywords = "Childhood leukemia, genotype, hOGG1, polymorphism, Taiwan",

author = "Hsu, {Pei Chen} and Chen, {Chao Chun} and Tzeng, {Huey En} and Hsu, {Yuan Nian} and Kuo, {Chien Chung} and Lin, {Meng Liang} and Chang, {Wen Shin} and Wang, {Yun Chi} and Tsai, {Chia Wen} and Pei, {Jen Sheng} and Bau, {DA Tian}",

note = "Funding Information: The Authors are grateful to Hsin-Ting Li and Huai-Mei Hsu for their excellent technical assistance. All the participants in this study are appreciated. This study was supported mainly by Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan, ROC to Dr. Hsu (grant number: PTH108019). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All rights reserved.",

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language = "English",

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T1 - HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

AU - Hsu, Pei Chen

AU - Chen, Chao Chun

AU - Tzeng, Huey En

AU - Hsu, Yuan Nian

AU - Kuo, Chien Chung

AU - Lin, Meng Liang

AU - Chang, Wen Shin

AU - Wang, Yun Chi

AU - Tsai, Chia Wen

AU - Pei, Jen Sheng

AU - Bau, DA Tian

N1 - Funding Information: The Authors are grateful to Hsin-Ting Li and Huai-Mei Hsu for their excellent technical assistance. All the participants in this study are appreciated. This study was supported mainly by Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan, ROC to Dr. Hsu (grant number: PTH108019). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: © 2019 International Institute of Anticancer Research. All rights reserved.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

AB - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

KW - Childhood leukemia

KW - genotype

KW - hOGG1

KW - polymorphism

KW - Taiwan

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HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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