HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Pei Chen Hsu, Chao Chun Chen, Huey En Tzeng, Yuan Nian Hsu, Chien Chung Kuo, Meng Liang Lin, Wen Shin Chang, Yun Chi Wang, Chia Wen Tsai, Jen Sheng Pei, DA Tian Bau

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Abstract

BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalIn vivo (Athens, Greece)
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 1 2019

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Keywords

  • Childhood leukemia
  • genotype
  • hOGG1
  • polymorphism
  • Taiwan

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Hsu, P. C., Chen, C. C., Tzeng, H. E., Hsu, Y. N., Kuo, C. C., Lin, M. L., Chang, W. S., Wang, Y. C., Tsai, C. W., Pei, J. S., & Bau, DA. T. (2019). HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population. In vivo (Athens, Greece), 33(4), 1081-1086. https://doi.org/10.21873/invivo.11576