HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population

Pei Chen Hsu, Chao Chun Chen, Huey En Tzeng, Yuan Nian Hsu, Chien Chung Kuo, Meng Liang Lin, Wen Shin Chang, Yun Chi Wang, Chia Wen Tsai, Jen Sheng Pei, DA Tian Bau

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalIn vivo (Athens, Greece)
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 1 2019

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DNA Glycosylases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genotype
Population
Polymorphism
Mountings
Human Activities
DNA Repair
DNA Damage
Repair
Genes
Odds Ratio
Genome
Confidence Intervals
Control Groups
DNA

Keywords

  • Childhood leukemia
  • genotype
  • hOGG1
  • polymorphism
  • Taiwan

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population. / Hsu, Pei Chen; Chen, Chao Chun; Tzeng, Huey En; Hsu, Yuan Nian; Kuo, Chien Chung; Lin, Meng Liang; Chang, Wen Shin; Wang, Yun Chi; Tsai, Chia Wen; Pei, Jen Sheng; Bau, DA Tian.

In: In vivo (Athens, Greece), Vol. 33, No. 4, 01.07.2019, p. 1081-1086.

Research output: Contribution to journalArticle

Hsu, PC, Chen, CC, Tzeng, HE, Hsu, YN, Kuo, CC, Lin, ML, Chang, WS, Wang, YC, Tsai, CW, Pei, JS & Bau, DAT 2019, 'HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population', In vivo (Athens, Greece), vol. 33, no. 4, pp. 1081-1086. https://doi.org/10.21873/invivo.11576
Hsu, Pei Chen ; Chen, Chao Chun ; Tzeng, Huey En ; Hsu, Yuan Nian ; Kuo, Chien Chung ; Lin, Meng Liang ; Chang, Wen Shin ; Wang, Yun Chi ; Tsai, Chia Wen ; Pei, Jen Sheng ; Bau, DA Tian. / HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population. In: In vivo (Athens, Greece). 2019 ; Vol. 33, No. 4. pp. 1081-1086.
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AU - Tzeng, Huey En

AU - Hsu, Yuan Nian

AU - Kuo, Chien Chung

AU - Lin, Meng Liang

AU - Chang, Wen Shin

AU - Wang, Yun Chi

AU - Tsai, Chia Wen

AU - Pei, Jen Sheng

AU - Bau, DA Tian

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N2 - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

AB - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.

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