Abstract
BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 1081-1086 |
| Number of pages | 6 |
| Journal | In vivo (Athens, Greece) |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2019 |
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Keywords
- Childhood leukemia
- genotype
- hOGG1
- polymorphism
- Taiwan
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
Cite this
HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population. / Hsu, Pei Chen; Chen, Chao Chun; Tzeng, Huey En; Hsu, Yuan Nian; Kuo, Chien Chung; Lin, Meng Liang; Chang, Wen Shin; Wang, Yun Chi; Tsai, Chia Wen; Pei, Jen Sheng; Bau, DA Tian.
In: In vivo (Athens, Greece), Vol. 33, No. 4, 01.07.2019, p. 1081-1086.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HOGG1 rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population
AU - Hsu, Pei Chen
AU - Chen, Chao Chun
AU - Tzeng, Huey En
AU - Hsu, Yuan Nian
AU - Kuo, Chien Chung
AU - Lin, Meng Liang
AU - Chang, Wen Shin
AU - Wang, Yun Chi
AU - Tsai, Chia Wen
AU - Pei, Jen Sheng
AU - Bau, DA Tian
PY - 2019/7/1
Y1 - 2019/7/1
N2 - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.
AB - BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls. RESULTS: The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947). CONCLUSION: The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.
KW - Childhood leukemia
KW - genotype
KW - hOGG1
KW - polymorphism
KW - Taiwan
UR - http://www.scopus.com/inward/record.url?scp=85069293465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069293465&partnerID=8YFLogxK
U2 - 10.21873/invivo.11576
DO - 10.21873/invivo.11576
M3 - Article
C2 - 31280195
AN - SCOPUS:85069293465
VL - 33
SP - 1081
EP - 1086
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 4
ER -