HLA-A33 is associated with susceptibility to enterovirus 71 infection

Luan Yin Chang, I. Shou Chang, Wei Jen Chen, Yhu Cherng Huang, Guang Wu Chen, Shin Ru Shih, Jyh Lyh Juang, Hsiu Ming Shih, Chao A. Hsiung, Tzou Yien Lin, Lin Min Huang

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

OBJECTIVE. Enterovirus 71 has caused large epidemics of disease, resulting in many fatalities and severe sequelae, in Taiwan and some other countries. In this study, host genetic factors were investigated to link susceptibility to and clinical severity of enterovirus 71 infections. METHODS. We enrolled 219 enterovirus 71 case subjects and 97 control children. HLA typing was performed with sequence-specific primers, and polymorphisms of immune-related candidate genes were detected with polymerase chain reaction, followed by automated gene sequencing. RESULTS. Of the 219 enterovirus 71 cases, 26% (56 of 219 cases) were uncomplicated cases, 74% (163 of 219 cases) were complicated cases, 57% (125 of 219 cases) were complicated cases with central nervous system involvement, and 17% (38 of 219 cases) involved cardiopulmonary failure after central nervous system involvement. Univariate analyses showed that tumor necrosis factor α promoter type II (-308 A allele), HLA-A33, and HLA-DR17 were significantly associated with enterovirus 71 susceptibility. Multivariate analysis demonstrated that HLA-A33 was the gene most significantly susceptible to enterovirus 71. HLA-A2 was associated with the development of cardiopulmonary failure. CONCLUSIONS. HLA-A33, which is a common phenotype in Asian populations but is rare in white populations, was most significantly associated with enterovirus 71 infection, compared with the other candidate genes we studied, whereas HLA-A2 was significantly related to cardiopulmonary failure. Copyright by the American Academy of Pediatrics.

Original languageEnglish
Pages (from-to)1271-1276
Number of pages6
JournalPediatrics
Volume122
Issue number6
DOIs
Publication statusPublished - Dec 2008
Externally publishedYes

Fingerprint

HLA-A*33 antigen
Enterovirus Infections
Enterovirus
HLA-A2 Antigen
Genes
Central Nervous System
Histocompatibility Testing
Taiwan
Population
Multivariate Analysis
Tumor Necrosis Factor-alpha
Alleles
Phenotype
Polymerase Chain Reaction

Keywords

  • Enterovirus 71
  • HLA-A33
  • Susceptibility

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chang, L. Y., Chang, I. S., Chen, W. J., Huang, Y. C., Chen, G. W., Shih, S. R., ... Huang, L. M. (2008). HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics, 122(6), 1271-1276. https://doi.org/10.1542/peds.2007-3735

HLA-A33 is associated with susceptibility to enterovirus 71 infection. / Chang, Luan Yin; Chang, I. Shou; Chen, Wei Jen; Huang, Yhu Cherng; Chen, Guang Wu; Shih, Shin Ru; Juang, Jyh Lyh; Shih, Hsiu Ming; Hsiung, Chao A.; Lin, Tzou Yien; Huang, Lin Min.

In: Pediatrics, Vol. 122, No. 6, 12.2008, p. 1271-1276.

Research output: Contribution to journalArticle

Chang, LY, Chang, IS, Chen, WJ, Huang, YC, Chen, GW, Shih, SR, Juang, JL, Shih, HM, Hsiung, CA, Lin, TY & Huang, LM 2008, 'HLA-A33 is associated with susceptibility to enterovirus 71 infection', Pediatrics, vol. 122, no. 6, pp. 1271-1276. https://doi.org/10.1542/peds.2007-3735
Chang LY, Chang IS, Chen WJ, Huang YC, Chen GW, Shih SR et al. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008 Dec;122(6):1271-1276. https://doi.org/10.1542/peds.2007-3735
Chang, Luan Yin ; Chang, I. Shou ; Chen, Wei Jen ; Huang, Yhu Cherng ; Chen, Guang Wu ; Shih, Shin Ru ; Juang, Jyh Lyh ; Shih, Hsiu Ming ; Hsiung, Chao A. ; Lin, Tzou Yien ; Huang, Lin Min. / HLA-A33 is associated with susceptibility to enterovirus 71 infection. In: Pediatrics. 2008 ; Vol. 122, No. 6. pp. 1271-1276.
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abstract = "OBJECTIVE. Enterovirus 71 has caused large epidemics of disease, resulting in many fatalities and severe sequelae, in Taiwan and some other countries. In this study, host genetic factors were investigated to link susceptibility to and clinical severity of enterovirus 71 infections. METHODS. We enrolled 219 enterovirus 71 case subjects and 97 control children. HLA typing was performed with sequence-specific primers, and polymorphisms of immune-related candidate genes were detected with polymerase chain reaction, followed by automated gene sequencing. RESULTS. Of the 219 enterovirus 71 cases, 26{\%} (56 of 219 cases) were uncomplicated cases, 74{\%} (163 of 219 cases) were complicated cases, 57{\%} (125 of 219 cases) were complicated cases with central nervous system involvement, and 17{\%} (38 of 219 cases) involved cardiopulmonary failure after central nervous system involvement. Univariate analyses showed that tumor necrosis factor α promoter type II (-308 A allele), HLA-A33, and HLA-DR17 were significantly associated with enterovirus 71 susceptibility. Multivariate analysis demonstrated that HLA-A33 was the gene most significantly susceptible to enterovirus 71. HLA-A2 was associated with the development of cardiopulmonary failure. CONCLUSIONS. HLA-A33, which is a common phenotype in Asian populations but is rare in white populations, was most significantly associated with enterovirus 71 infection, compared with the other candidate genes we studied, whereas HLA-A2 was significantly related to cardiopulmonary failure. Copyright by the American Academy of Pediatrics.",
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AU - Chang, Luan Yin

AU - Chang, I. Shou

AU - Chen, Wei Jen

AU - Huang, Yhu Cherng

AU - Chen, Guang Wu

AU - Shih, Shin Ru

AU - Juang, Jyh Lyh

AU - Shih, Hsiu Ming

AU - Hsiung, Chao A.

AU - Lin, Tzou Yien

AU - Huang, Lin Min

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N2 - OBJECTIVE. Enterovirus 71 has caused large epidemics of disease, resulting in many fatalities and severe sequelae, in Taiwan and some other countries. In this study, host genetic factors were investigated to link susceptibility to and clinical severity of enterovirus 71 infections. METHODS. We enrolled 219 enterovirus 71 case subjects and 97 control children. HLA typing was performed with sequence-specific primers, and polymorphisms of immune-related candidate genes were detected with polymerase chain reaction, followed by automated gene sequencing. RESULTS. Of the 219 enterovirus 71 cases, 26% (56 of 219 cases) were uncomplicated cases, 74% (163 of 219 cases) were complicated cases, 57% (125 of 219 cases) were complicated cases with central nervous system involvement, and 17% (38 of 219 cases) involved cardiopulmonary failure after central nervous system involvement. Univariate analyses showed that tumor necrosis factor α promoter type II (-308 A allele), HLA-A33, and HLA-DR17 were significantly associated with enterovirus 71 susceptibility. Multivariate analysis demonstrated that HLA-A33 was the gene most significantly susceptible to enterovirus 71. HLA-A2 was associated with the development of cardiopulmonary failure. CONCLUSIONS. HLA-A33, which is a common phenotype in Asian populations but is rare in white populations, was most significantly associated with enterovirus 71 infection, compared with the other candidate genes we studied, whereas HLA-A2 was significantly related to cardiopulmonary failure. Copyright by the American Academy of Pediatrics.

AB - OBJECTIVE. Enterovirus 71 has caused large epidemics of disease, resulting in many fatalities and severe sequelae, in Taiwan and some other countries. In this study, host genetic factors were investigated to link susceptibility to and clinical severity of enterovirus 71 infections. METHODS. We enrolled 219 enterovirus 71 case subjects and 97 control children. HLA typing was performed with sequence-specific primers, and polymorphisms of immune-related candidate genes were detected with polymerase chain reaction, followed by automated gene sequencing. RESULTS. Of the 219 enterovirus 71 cases, 26% (56 of 219 cases) were uncomplicated cases, 74% (163 of 219 cases) were complicated cases, 57% (125 of 219 cases) were complicated cases with central nervous system involvement, and 17% (38 of 219 cases) involved cardiopulmonary failure after central nervous system involvement. Univariate analyses showed that tumor necrosis factor α promoter type II (-308 A allele), HLA-A33, and HLA-DR17 were significantly associated with enterovirus 71 susceptibility. Multivariate analysis demonstrated that HLA-A33 was the gene most significantly susceptible to enterovirus 71. HLA-A2 was associated with the development of cardiopulmonary failure. CONCLUSIONS. HLA-A33, which is a common phenotype in Asian populations but is rare in white populations, was most significantly associated with enterovirus 71 infection, compared with the other candidate genes we studied, whereas HLA-A2 was significantly related to cardiopulmonary failure. Copyright by the American Academy of Pediatrics.

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