HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan

Yung Feng Yen, I. An Jen, Marcelo Chen, Yu Ching Lan, Chun Yuan Lee, Pei Hung Chuang, Yun Lee, Yi Ming Arthur Chen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. Objectives: The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. Methods: Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event. Results: Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36). Conclusions: The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume75
Issue number5
DOIs
Publication statusPublished - Aug 15 2017
Externally publishedYes

Fingerprint

Taiwan
Psoriasis
HIV Infections
Cohort Studies
HIV
Population
Acquired Immunodeficiency Syndrome
National Health Programs
Proportional Hazards Models
Comorbidity
Databases
Confidence Intervals
T-Lymphocytes
Research

Keywords

  • cohort
  • HIV
  • psoriasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

HIV Infection Increases the Risk of Incident Psoriasis : A Nationwide Population-Based Cohort Study in Taiwan. / Yen, Yung Feng; Jen, I. An; Chen, Marcelo; Lan, Yu Ching; Lee, Chun Yuan; Chuang, Pei Hung; Lee, Yun; Arthur Chen, Yi Ming.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 75, No. 5, 15.08.2017, p. 493-499.

Research output: Contribution to journalArticle

Yen, Yung Feng ; Jen, I. An ; Chen, Marcelo ; Lan, Yu Ching ; Lee, Chun Yuan ; Chuang, Pei Hung ; Lee, Yun ; Arthur Chen, Yi Ming. / HIV Infection Increases the Risk of Incident Psoriasis : A Nationwide Population-Based Cohort Study in Taiwan. In: Journal of Acquired Immune Deficiency Syndromes. 2017 ; Vol. 75, No. 5. pp. 493-499.
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