HIV 10 years later - Where do we stand now?

L. J. Chang, Y. M.A. Chen, M. Y. Chen, C. C. Chou, S. J. Twu, L. M. Huang

Research output: Contribution to journalConference article

Abstract

A wide variety of up-to-date results and knowledge were presented at the 10th International AIDS Meeting, Yokohama. Epidemiologically, most interest was focused on the discovery of a new HIV subtype O, which cannot be reliably detected by currently available ELISA kits. Clinically, it is gradually appreciated that one single most important parameter is the viral load; the extent of viral load can help explain many clinical observations. Another eye-catching finding was the report of a clinical follow-up of a group of long-term nonprogressors. If the underlying operative mechanism can be elucidated, we can learn the necessary elements for halting HIV infection progression. Therapeutically, the trend has shifted to combination therapy, preferentially 3-drug combination of 2 RT inhibitors and 1 protease inhibitor. For the vaccine development, many novel vectors were introduced, but their potentials are unknown at present. The successful application of single-cell in situ PCR has changed our perception of HIV infection. This powerful technique can detect a single viral genome inside cells and revealed that a large proportion of cells already harbor HIV genomes soon after the entry of HIV into the body. A direct viral effect may fully explain subsequent T cell depletion without invoking a lot of indirect mechanisms such as apoptosis.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Biomedical Science
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 25 1995
Externally publishedYes

Fingerprint

Genes
HIV
Viral Load
HIV Infections
T-cells
Drug Combinations
Ports and harbors
Protease Inhibitors
Vaccines
Viral Genome
Apoptosis
Acquired Immunodeficiency Syndrome
Enzyme-Linked Immunosorbent Assay
Genome
T-Lymphocytes
Polymerase Chain Reaction
Therapeutics
Knowledge of Results (Psychology)

Keywords

  • AIDS
  • Epidemiology
  • HIV

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Chang, L. J., Chen, Y. M. A., Chen, M. Y., Chou, C. C., Twu, S. J., & Huang, L. M. (1995). HIV 10 years later - Where do we stand now? Journal of Biomedical Science, 2(1), 1-11. https://doi.org/10.1007/BF02257919

HIV 10 years later - Where do we stand now? / Chang, L. J.; Chen, Y. M.A.; Chen, M. Y.; Chou, C. C.; Twu, S. J.; Huang, L. M.

In: Journal of Biomedical Science, Vol. 2, No. 1, 25.01.1995, p. 1-11.

Research output: Contribution to journalConference article

Chang, LJ, Chen, YMA, Chen, MY, Chou, CC, Twu, SJ & Huang, LM 1995, 'HIV 10 years later - Where do we stand now?', Journal of Biomedical Science, vol. 2, no. 1, pp. 1-11. https://doi.org/10.1007/BF02257919
Chang, L. J. ; Chen, Y. M.A. ; Chen, M. Y. ; Chou, C. C. ; Twu, S. J. ; Huang, L. M. / HIV 10 years later - Where do we stand now?. In: Journal of Biomedical Science. 1995 ; Vol. 2, No. 1. pp. 1-11.
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