Higher ventricular premature complex burden is associated with lower systolic blood pressure response

Jing Wei Kang, Wei Hsiang Yang, Jia En Chi, Wei Ta Chen

Research output: Contribution to journalArticle

Abstract

Background: Ventricular premature complexes (VPCs) with a burden higher than 10% to 20% of total daily heart beats can cause VPC-induced cardiomyopathy. The systolic blood pressure response (SBPR) is the difference between the SBP during maximal exercise and rest. A low SBPR was recently identified to be a marker of cardiomyopathy. The aim of this manuscript was to clarify the association between VPC burden and SBPR. Methods: From January to December 2015, all patients with a VPC burden larger than 240 beats/day on Holter recordings and treadmill exercise tests were enrolled. The patients with a heart rhythm other than sinus rhythm, coronary artery disease, and severe cardiomyopathy were excluded. The SBPR was measured during a treadmill test. The basic characteristics and echocardiographic findings were collected. Results: All patients were classified into three groups: Group 1; 240-1,000 VPCs/day (n = 78), Group 2; 1,000-10,000 VPCs/day (n = 54), and Group 3; > 10,000 VPCs/day (n = 21). Group 1 had a higher SBPR than the other groups. Multivariate analysis revealed that only VPC burden was associated with SBPR. Receiver operating characteristic curve analysis showed that a VPC burden > 1,055 beats/day predicted a SBPR < 40 mmHg. The results were consistent in all subgroups. There were no significant differences in echocardiographic findings among the groups. Conclusions: AVPC burden higher than 1,055 beats/day was associated with a reduced SBPR.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalActa Cardiologica Sinica
Volume34
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

Fingerprint

Ventricular Premature Complexes
Blood Pressure
Cardiomyopathies
Exercise Test
ROC Curve
Hypotension
Coronary Artery Disease

Keywords

  • Cardiomyopathy
  • Systolic blood pressure response
  • Ventricular premature complex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Higher ventricular premature complex burden is associated with lower systolic blood pressure response. / Kang, Jing Wei; Yang, Wei Hsiang; Chi, Jia En; Chen, Wei Ta.

In: Acta Cardiologica Sinica, Vol. 34, No. 2, 01.03.2018, p. 152-158.

Research output: Contribution to journalArticle

Kang, Jing Wei ; Yang, Wei Hsiang ; Chi, Jia En ; Chen, Wei Ta. / Higher ventricular premature complex burden is associated with lower systolic blood pressure response. In: Acta Cardiologica Sinica. 2018 ; Vol. 34, No. 2. pp. 152-158.
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