Abstract

Objective: We studied the risk of dementia in patients with primary Sjögren's syndrome (pSS) using a nationwide, population-based cohort in Taiwan. Methods: Our study analyzed the medical data of the Taiwanese population from 2000 to 2014. We identified 17,072 patients with pSS and 68,270 controls. Dementia risk was analyzed using a Cox proportional hazards regression model stratified by sex, age, and comorbidities. Results: A higher incidence of dementia development in the pSS group during the observation period (P = 0.0001). In multivariate analysis adjusted by age groups, gender, and the comorbidities, the adjusted hazard ratio (aHR) of developing dementia was 1.246 (95% CI 1.123–1.384) times greater in the pSS group than in the non-pSS group. When stratified by sex, age, and comorbidities, the patients with pSS less than 60 years (aHR 1.67, 95% CI 1.16–2.41), and without any comorbidity (aHR 2.27, 95% CI 1.76–2.93) were particularly associated with a higher risk of dementia. Furthermore, the patients with pSS combined with any other comorbidity had an additionally higher risk of dementia (aHR: 3.978, 95% CI 3.309–4.782), also suggesting that pSS was an independent risk factor for the development of dementia. Interpretation: Primary Sjogren's syndrome is associated with increased dementia risk and further study is needed to understand why and what the specific dementia phenotypes are.

Original languageEnglish
Pages (from-to)633-641
Number of pages9
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

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Sjogren's Syndrome
Dementia
Comorbidity
Taiwan
Proportional Hazards Models
Population
Multivariate Analysis
Age Groups
Observation
Phenotype
Incidence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Higher risk of dementia in primary Sjogren's syndrome. / Hou, Tsung Yun; Hsu, Hui Ching; Lin, Tzu Min; Chang, Yu Sheng; Chen, Wei Sheng; Kuo, Pei I.; Lin, Yi Chun; Chang, Chi Ching; Chen, Jin Hua.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 4, 01.04.2019, p. 633-641.

Research output: Contribution to journalArticle

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abstract = "Objective: We studied the risk of dementia in patients with primary Sj{\"o}gren's syndrome (pSS) using a nationwide, population-based cohort in Taiwan. Methods: Our study analyzed the medical data of the Taiwanese population from 2000 to 2014. We identified 17,072 patients with pSS and 68,270 controls. Dementia risk was analyzed using a Cox proportional hazards regression model stratified by sex, age, and comorbidities. Results: A higher incidence of dementia development in the pSS group during the observation period (P = 0.0001). In multivariate analysis adjusted by age groups, gender, and the comorbidities, the adjusted hazard ratio (aHR) of developing dementia was 1.246 (95{\%} CI 1.123–1.384) times greater in the pSS group than in the non-pSS group. When stratified by sex, age, and comorbidities, the patients with pSS less than 60 years (aHR 1.67, 95{\%} CI 1.16–2.41), and without any comorbidity (aHR 2.27, 95{\%} CI 1.76–2.93) were particularly associated with a higher risk of dementia. Furthermore, the patients with pSS combined with any other comorbidity had an additionally higher risk of dementia (aHR: 3.978, 95{\%} CI 3.309–4.782), also suggesting that pSS was an independent risk factor for the development of dementia. Interpretation: Primary Sjogren's syndrome is associated with increased dementia risk and further study is needed to understand why and what the specific dementia phenotypes are.",
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T1 - Higher risk of dementia in primary Sjogren's syndrome

AU - Hou, Tsung Yun

AU - Hsu, Hui Ching

AU - Lin, Tzu Min

AU - Chang, Yu Sheng

AU - Chen, Wei Sheng

AU - Kuo, Pei I.

AU - Lin, Yi Chun

AU - Chang, Chi Ching

AU - Chen, Jin Hua

PY - 2019/4/1

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N2 - Objective: We studied the risk of dementia in patients with primary Sjögren's syndrome (pSS) using a nationwide, population-based cohort in Taiwan. Methods: Our study analyzed the medical data of the Taiwanese population from 2000 to 2014. We identified 17,072 patients with pSS and 68,270 controls. Dementia risk was analyzed using a Cox proportional hazards regression model stratified by sex, age, and comorbidities. Results: A higher incidence of dementia development in the pSS group during the observation period (P = 0.0001). In multivariate analysis adjusted by age groups, gender, and the comorbidities, the adjusted hazard ratio (aHR) of developing dementia was 1.246 (95% CI 1.123–1.384) times greater in the pSS group than in the non-pSS group. When stratified by sex, age, and comorbidities, the patients with pSS less than 60 years (aHR 1.67, 95% CI 1.16–2.41), and without any comorbidity (aHR 2.27, 95% CI 1.76–2.93) were particularly associated with a higher risk of dementia. Furthermore, the patients with pSS combined with any other comorbidity had an additionally higher risk of dementia (aHR: 3.978, 95% CI 3.309–4.782), also suggesting that pSS was an independent risk factor for the development of dementia. Interpretation: Primary Sjogren's syndrome is associated with increased dementia risk and further study is needed to understand why and what the specific dementia phenotypes are.

AB - Objective: We studied the risk of dementia in patients with primary Sjögren's syndrome (pSS) using a nationwide, population-based cohort in Taiwan. Methods: Our study analyzed the medical data of the Taiwanese population from 2000 to 2014. We identified 17,072 patients with pSS and 68,270 controls. Dementia risk was analyzed using a Cox proportional hazards regression model stratified by sex, age, and comorbidities. Results: A higher incidence of dementia development in the pSS group during the observation period (P = 0.0001). In multivariate analysis adjusted by age groups, gender, and the comorbidities, the adjusted hazard ratio (aHR) of developing dementia was 1.246 (95% CI 1.123–1.384) times greater in the pSS group than in the non-pSS group. When stratified by sex, age, and comorbidities, the patients with pSS less than 60 years (aHR 1.67, 95% CI 1.16–2.41), and without any comorbidity (aHR 2.27, 95% CI 1.76–2.93) were particularly associated with a higher risk of dementia. Furthermore, the patients with pSS combined with any other comorbidity had an additionally higher risk of dementia (aHR: 3.978, 95% CI 3.309–4.782), also suggesting that pSS was an independent risk factor for the development of dementia. Interpretation: Primary Sjogren's syndrome is associated with increased dementia risk and further study is needed to understand why and what the specific dementia phenotypes are.

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