Higher platelet counts are associated with metabolic syndrome independent of fatty liver diagnosis

Kuan Chieh Fang, Yuan Lung Cheng, Chien Wei Su, Yuan Jen Wang, Keng Hsin Lan, Teh Ia Huo, Yi Hsiang Huang, Chi Jen Chu, Chung Chi Lin, Ming Chih Hou, Han Chieh Lin, Fa Yauh Lee, Jaw Ching Wu, Shou Dong Lee

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background Platelet count (PC) and fatty liver are both associated with metabolic syndrome (MS), obesity, and type 2 diabetes. While PC increases in obesity and type 2 diabetes, the severity of hepatic fibrosis caused by fatty liver reduces PC. We aimed to investigate the correlation of PC and MS in patients with and without fatty liver. Methods We enrolled consecutive patients who received health check-ups at Taipei Veterans General Hospital from 2002 to 2009. Ultrasonography was used to diagnose fatty liver, and MS was diagnosed according to the criteria defined by the International Diabetes Federation Task Force on Epidemiology and Prevention. Results Among the 29,797 patients, MS was present in 28.74%. Higher PC was correlated with MS using multivariate analysis, while fatty liver had the strongest association with MS. After dividing the patients by the presence or absence of fatty liver, higher PC was still associated with MS in both groups. The patients were further stratified by age and gender, and MS was correlated with PC among all age groups in women and in men under 60 years of age; however, the association between PC and MS did not reach statistical difference in men older than 60 years. Conclusion There is a significant correlation between PC and MS, and the correlation exists independent of gender, age, and fatty liver. PC may act as a surrogate marker for MS, and physicians should be concerned with the presence of MS among patients with high PC.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalJournal of the Chinese Medical Association
Issue number3
Publication statusPublished - Mar 1 2017
Externally publishedYes


  • body mass index
  • fatty liver disease
  • metabolic syndrome
  • platelet count
  • sonography

ASJC Scopus subject areas

  • Medicine(all)


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