Higher normal range of fasting plasma glucose still has a higher risk for metabolic syndrome: A combined cross-sectional and longitudinal study in elderly

S. H. Wei, J. D. Lin, C. H. Hsu, C. Z. Wu, C. H. Hsieh, D. Pei, J. B. Chang, Y. J. Liang, T. L. Hsia, Y. L. Chen

Research output: Contribution to journalArticle

Abstract

Introduction It is well known that higher fasting plasma glucose (FPG) is associated with metabolic syndrome (MetS). This relationship still exists even the FPG is within the normal range. However, most of these studies did not exclude subjects who were on medications which would affect the results of the studies. At the same time, there is no longitudinal study done to validate this correlation, especially in elderly. In this study, the relationships between normal FPG and MetS were evaluated. Method We randomly selected 57,517 subjects who were ≥ 60-years old from health screening centre. In the first part of study, subjects were enrolled in the cross-sectional study to find out the optimal cut-off value of FPG with higher chances to have MetS. In the second part of current study, subjects with MetS at baseline were excluded from the same study group, and performed a median 5.3-year longitudinal study. Results There were 18,287 subjects enrolled in this study. In the first part of study, the cross-sectional study, optimal cut-off values of FPG were determined by the ROC curve and the sensitivity for these cut-off values were 56.6% in men and 60.9% in women, respectively. The result showed that lower FPG is healthier than the higher (log-rank test, p <0.001). During the follow-up period, 5039 subjects showed hazard ratios of 2.09 for men and 1.884 for women developing future MetS. Conclusion Our study is the first longitudinal design in elderly and showed that older subjects with higher FPG proved to have higher risk of Mets even the FPG is still within its normal range.

Original languageEnglish
Pages (from-to)863-870
Number of pages8
JournalInternational Journal of Clinical Practice
Volume69
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Longitudinal Studies
Fasting
Reference Values
Cross-Sectional Studies
Glucose
ROC Curve
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Higher normal range of fasting plasma glucose still has a higher risk for metabolic syndrome : A combined cross-sectional and longitudinal study in elderly. / Wei, S. H.; Lin, J. D.; Hsu, C. H.; Wu, C. Z.; Hsieh, C. H.; Pei, D.; Chang, J. B.; Liang, Y. J.; Hsia, T. L.; Chen, Y. L.

In: International Journal of Clinical Practice, Vol. 69, No. 8, 01.08.2015, p. 863-870.

Research output: Contribution to journalArticle

Wei, S. H. ; Lin, J. D. ; Hsu, C. H. ; Wu, C. Z. ; Hsieh, C. H. ; Pei, D. ; Chang, J. B. ; Liang, Y. J. ; Hsia, T. L. ; Chen, Y. L. / Higher normal range of fasting plasma glucose still has a higher risk for metabolic syndrome : A combined cross-sectional and longitudinal study in elderly. In: International Journal of Clinical Practice. 2015 ; Vol. 69, No. 8. pp. 863-870.
@article{452f4e26cad34d048f3e4ed22daaed31,
title = "Higher normal range of fasting plasma glucose still has a higher risk for metabolic syndrome: A combined cross-sectional and longitudinal study in elderly",
abstract = "Introduction It is well known that higher fasting plasma glucose (FPG) is associated with metabolic syndrome (MetS). This relationship still exists even the FPG is within the normal range. However, most of these studies did not exclude subjects who were on medications which would affect the results of the studies. At the same time, there is no longitudinal study done to validate this correlation, especially in elderly. In this study, the relationships between normal FPG and MetS were evaluated. Method We randomly selected 57,517 subjects who were ≥ 60-years old from health screening centre. In the first part of study, subjects were enrolled in the cross-sectional study to find out the optimal cut-off value of FPG with higher chances to have MetS. In the second part of current study, subjects with MetS at baseline were excluded from the same study group, and performed a median 5.3-year longitudinal study. Results There were 18,287 subjects enrolled in this study. In the first part of study, the cross-sectional study, optimal cut-off values of FPG were determined by the ROC curve and the sensitivity for these cut-off values were 56.6{\%} in men and 60.9{\%} in women, respectively. The result showed that lower FPG is healthier than the higher (log-rank test, p <0.001). During the follow-up period, 5039 subjects showed hazard ratios of 2.09 for men and 1.884 for women developing future MetS. Conclusion Our study is the first longitudinal design in elderly and showed that older subjects with higher FPG proved to have higher risk of Mets even the FPG is still within its normal range.",
author = "Wei, {S. H.} and Lin, {J. D.} and Hsu, {C. H.} and Wu, {C. Z.} and Hsieh, {C. H.} and D. Pei and Chang, {J. B.} and Liang, {Y. J.} and Hsia, {T. L.} and Chen, {Y. L.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1111/ijcp.12633",
language = "English",
volume = "69",
pages = "863--870",
journal = "International Journal of Clinical Practice",
issn = "1368-5031",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Higher normal range of fasting plasma glucose still has a higher risk for metabolic syndrome

T2 - A combined cross-sectional and longitudinal study in elderly

AU - Wei, S. H.

AU - Lin, J. D.

AU - Hsu, C. H.

AU - Wu, C. Z.

AU - Hsieh, C. H.

AU - Pei, D.

AU - Chang, J. B.

AU - Liang, Y. J.

AU - Hsia, T. L.

AU - Chen, Y. L.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Introduction It is well known that higher fasting plasma glucose (FPG) is associated with metabolic syndrome (MetS). This relationship still exists even the FPG is within the normal range. However, most of these studies did not exclude subjects who were on medications which would affect the results of the studies. At the same time, there is no longitudinal study done to validate this correlation, especially in elderly. In this study, the relationships between normal FPG and MetS were evaluated. Method We randomly selected 57,517 subjects who were ≥ 60-years old from health screening centre. In the first part of study, subjects were enrolled in the cross-sectional study to find out the optimal cut-off value of FPG with higher chances to have MetS. In the second part of current study, subjects with MetS at baseline were excluded from the same study group, and performed a median 5.3-year longitudinal study. Results There were 18,287 subjects enrolled in this study. In the first part of study, the cross-sectional study, optimal cut-off values of FPG were determined by the ROC curve and the sensitivity for these cut-off values were 56.6% in men and 60.9% in women, respectively. The result showed that lower FPG is healthier than the higher (log-rank test, p <0.001). During the follow-up period, 5039 subjects showed hazard ratios of 2.09 for men and 1.884 for women developing future MetS. Conclusion Our study is the first longitudinal design in elderly and showed that older subjects with higher FPG proved to have higher risk of Mets even the FPG is still within its normal range.

AB - Introduction It is well known that higher fasting plasma glucose (FPG) is associated with metabolic syndrome (MetS). This relationship still exists even the FPG is within the normal range. However, most of these studies did not exclude subjects who were on medications which would affect the results of the studies. At the same time, there is no longitudinal study done to validate this correlation, especially in elderly. In this study, the relationships between normal FPG and MetS were evaluated. Method We randomly selected 57,517 subjects who were ≥ 60-years old from health screening centre. In the first part of study, subjects were enrolled in the cross-sectional study to find out the optimal cut-off value of FPG with higher chances to have MetS. In the second part of current study, subjects with MetS at baseline were excluded from the same study group, and performed a median 5.3-year longitudinal study. Results There were 18,287 subjects enrolled in this study. In the first part of study, the cross-sectional study, optimal cut-off values of FPG were determined by the ROC curve and the sensitivity for these cut-off values were 56.6% in men and 60.9% in women, respectively. The result showed that lower FPG is healthier than the higher (log-rank test, p <0.001). During the follow-up period, 5039 subjects showed hazard ratios of 2.09 for men and 1.884 for women developing future MetS. Conclusion Our study is the first longitudinal design in elderly and showed that older subjects with higher FPG proved to have higher risk of Mets even the FPG is still within its normal range.

UR - http://www.scopus.com/inward/record.url?scp=84938205218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938205218&partnerID=8YFLogxK

U2 - 10.1111/ijcp.12633

DO - 10.1111/ijcp.12633

M3 - Article

C2 - 25757152

AN - SCOPUS:84938205218

VL - 69

SP - 863

EP - 870

JO - International Journal of Clinical Practice

JF - International Journal of Clinical Practice

SN - 1368-5031

IS - 8

ER -