High serum osteoprotegerin is associated with arterial stiffness in kidney transplant patients

Bang Gee Hsu, Ming Hui Shih, Yen Cheng Chen, Guan Jin Ho, Teng Yi Lin, Ming Che Lee

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Osteoprotegerin (OPG) is a cytokine that regulates bone resorption by inhibiting osteoclastogenesis, and OPG has been implicated in the process that causes vascular stiffness. An increase in serum OPG level has been associated with the development of arterial stiffness. Kidney transplant (KT) patients are susceptible to aortic stiffness, which is considered to be a predictor of cardiovascular events in this patient population. Carotid-femoral pulse wave velocity (cfPWV) has emerged as a gold standard for non-invasive evaluation of aortic stiffness. The aim of this study was to evaluate the relationship between serum OPG concentration and cfPWV among KT patients. Fasting blood samples were obtained from 57 KT patients and their cfPWV was measured using applanation tonometry. The serum OPG levels were measured using an enzyme-linked immunosorbent assay. Univariable linear regression analysis showed that the cfPWV in KT patients was significantly and positively correlated with age, body weight, waist circumference, body mass index, log-creatinine, systolic blood pressure, diastolic blood pressure, pulse pressure, and the log-OPG concentration. KT patients with metabolic syndrome had higher cfPWV values than those without metabolic syndrome (P = 0.036), which indicates a higher incidence of aortic stiffness in this patient population. Multivariable forward stepwise linear regression analysis of the significant variables showed that the log-OPG (P = 0.001), the log-creatinine (P = 0.004), and the SBP (P = 0.005) remained as independent and positive predictors of cfPWV values. These findings indicate that serum OPG levels are positively associated with cfPWV in KT patients.

Original languageEnglish
Article numberA02
Pages (from-to)247-253
Number of pages7
JournalTohoku Journal of Experimental Medicine
Issue number4
Publication statusPublished - 2015
Externally publishedYes


  • Arterial stiffness
  • Carotid-femoral pulse wave velocity
  • Kidney transplantation
  • Osteoprotegerin
  • Pulse pressure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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