High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

Sun Ma; Lih Ing Shieh; Chao Ching Huang

doi:10.1007/BF02783480

High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

Sun Ma, Lih Ing Shieh, Chao Ching Huang

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

Original language	English
Pages (from-to)	37-51
Number of pages	15
Journal	Applied Biochemistry and Biotechnology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1007/BF02783480
Publication status	Published - Apr 1995
Externally published	Yes

Keywords

H-NMR spectroscopy
Asphyxia
fetal distress
meconium aspiration syndrome
urine

ASJC Scopus subject areas

Bioengineering
Biotechnology
Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Applied Microbiology and Biotechnology
Environmental Engineering
Molecular Biology

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10.1007/BF02783480

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abstract = "High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.",

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T1 - High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

AU - Ma, Sun

AU - Shieh, Lih Ing

AU - Huang, Chao Ching

PY - 1995/4

Y1 - 1995/4

N2 - High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

AB - High-resolution proton nuclear magnetic resonance spectroscopy was used to study human urine obtained from 10 normal babies and twenty babies with various degrees of neonatal asphyxia, respiratory distress syndrome (RDS), and meconium aspiration syndrome (MAS). All sick babies showed different degrees of oxygen deficiency, indicated by an obvious increase of the lactate signal level in the urine spectra. Changes in the concentration of other urinary metabolites produced from the citric acid cycle were also observed. In extremely serious cases, the signals of some of the major components, including citrate, α-ketoglutarate, and succinate, simply disappeared. The spectra of urine, serum, and CSF of an infant suffering from SIDS showed common characteristics of the metabolites.

KW - H-NMR spectroscopy

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KW - fetal distress

KW - meconium aspiration syndrome

KW - urine

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High-resolution proton nuclear magnetic resonance studies of urine from asphyxiated newborn infants

Abstract

Keywords

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