High payload Gd(III) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging

Wan Ing Lin, Chien Yuan Lin, Yu Shen Lin, Si Han Wu, Yu Ru Huang, Yann Hung, Chen Chang, Chung Yuan Mou

Research output: Contribution to journalArticle

24 Citations (Scopus)


For clear MR imaging of blood vessels, a long blood circulation time of effective T1 contrast agents is necessary. Nanoparticulate MR contrast agents are much more effective owing to their enhanced relaxivity, a result of reduced tumbling rates, and large payloads of active magnetic species. PEGylated yolk-shell silica nanospheres containing high payloads of Gd(iii) with cross-linking ligands are synthesized and evaluated as a blood-pool magnetic resonance contrast agent. The hydrophilic PEG coating and the microporous silica shell allow water exchange while keeping the multi-nuclear Gd species from leaching out. These Gd(iii)-containing yolk-shell silica nanoparticles with PEGylated surfaces give excellent resolution and contrast in magnetic resonance angiography images of vasculature in rat brains.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalJournal of Materials Chemistry B
Issue number5
Publication statusPublished - Feb 7 2013
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

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