High payload Gd(III) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging

Wan Ing Lin, Chien Yuan Lin, Yu Shen Lin, Si-Han Wu, Yu Ru Huang, Yann Hung, Chen Chang, Chung Yuan Mou

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

For clear MR imaging of blood vessels, a long blood circulation time of effective T1 contrast agents is necessary. Nanoparticulate MR contrast agents are much more effective owing to their enhanced relaxivity, a result of reduced tumbling rates, and large payloads of active magnetic species. PEGylated yolk-shell silica nanospheres containing high payloads of Gd(iii) with cross-linking ligands are synthesized and evaluated as a blood-pool magnetic resonance contrast agent. The hydrophilic PEG coating and the microporous silica shell allow water exchange while keeping the multi-nuclear Gd species from leaching out. These Gd(iii)-containing yolk-shell silica nanoparticles with PEGylated surfaces give excellent resolution and contrast in magnetic resonance angiography images of vasculature in rat brains.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalJournal of Materials Chemistry B
Volume1
Issue number5
DOIs
Publication statusPublished - Feb 7 2013
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

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