Abstract

Objective: Patients with sleep apnea syndrome (SAS) carry a higher stroke risk. The differential stroke risk between sex and among different age groups has not yet been specifically addressed in previous studies. Methods: Using a universal insurance claims database, we identified a large cohort of SAS patients from 1997 to 2010 and assessed the sex- and age-specific stroke risk compared with a control cohort matched for age, sex, and index date. Cox regression analyses were performed to assess the hazard ratio (HR) of stroke and the corresponding 95% confidence interval (CI). Stroke-free probabilities were computed using the Kaplan-Meier method and differences between both cohorts were examined using the log-rank test. Results: We identified 29,961 patients with SAS and a control cohort of 119,844 subjects without SAS. The overall incidence of stroke in the SAS cohort was 37% higher compared to the non-SAS cohort (54.6 per 10,000 individual-years vs 39.8 per 10,000 individual-years). After controlling for sex and comorbidities, the SAS cohort exhibited a 19% higher risk for stroke compared to the control cohort (adjusted HR, 1.19 [95% CI, 1.09-1.30]). Women with SAS ages 35. years or younger had the highest stroke risk compared to older age groups of the same sex and their risk for stroke was relatively higher compared to their male counterparts. Conclusion: Women aged 35. years or younger with SAS have a higher stroke risk.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalSleep Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Sleep Apnea Syndromes
Stroke
Incidence
Age Groups
Confidence Intervals
Apnea
Insurance
Comorbidity
Regression Analysis
Databases

Keywords

  • Age
  • Cardiovascular
  • Sex
  • Sleep apnea
  • Sleep-disordered breathing
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

High incidence of stroke in young women with sleep apnea syndrome. / Chang, Chih-Cheng; Chuang, Hsiao Chi; Lin, Cheng Li; Sung, Fung Chang; Chang, Yen Jung; Hsu, Chung-Yi; Chiang, Ling Ling.

In: Sleep Medicine, Vol. 15, No. 4, 2014, p. 410-414.

Research output: Contribution to journalArticle

Chang, Chih-Cheng ; Chuang, Hsiao Chi ; Lin, Cheng Li ; Sung, Fung Chang ; Chang, Yen Jung ; Hsu, Chung-Yi ; Chiang, Ling Ling. / High incidence of stroke in young women with sleep apnea syndrome. In: Sleep Medicine. 2014 ; Vol. 15, No. 4. pp. 410-414.
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abstract = "Objective: Patients with sleep apnea syndrome (SAS) carry a higher stroke risk. The differential stroke risk between sex and among different age groups has not yet been specifically addressed in previous studies. Methods: Using a universal insurance claims database, we identified a large cohort of SAS patients from 1997 to 2010 and assessed the sex- and age-specific stroke risk compared with a control cohort matched for age, sex, and index date. Cox regression analyses were performed to assess the hazard ratio (HR) of stroke and the corresponding 95{\%} confidence interval (CI). Stroke-free probabilities were computed using the Kaplan-Meier method and differences between both cohorts were examined using the log-rank test. Results: We identified 29,961 patients with SAS and a control cohort of 119,844 subjects without SAS. The overall incidence of stroke in the SAS cohort was 37{\%} higher compared to the non-SAS cohort (54.6 per 10,000 individual-years vs 39.8 per 10,000 individual-years). After controlling for sex and comorbidities, the SAS cohort exhibited a 19{\%} higher risk for stroke compared to the control cohort (adjusted HR, 1.19 [95{\%} CI, 1.09-1.30]). Women with SAS ages 35. years or younger had the highest stroke risk compared to older age groups of the same sex and their risk for stroke was relatively higher compared to their male counterparts. Conclusion: Women aged 35. years or younger with SAS have a higher stroke risk.",
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T1 - High incidence of stroke in young women with sleep apnea syndrome

AU - Chang, Chih-Cheng

AU - Chuang, Hsiao Chi

AU - Lin, Cheng Li

AU - Sung, Fung Chang

AU - Chang, Yen Jung

AU - Hsu, Chung-Yi

AU - Chiang, Ling Ling

PY - 2014

Y1 - 2014

N2 - Objective: Patients with sleep apnea syndrome (SAS) carry a higher stroke risk. The differential stroke risk between sex and among different age groups has not yet been specifically addressed in previous studies. Methods: Using a universal insurance claims database, we identified a large cohort of SAS patients from 1997 to 2010 and assessed the sex- and age-specific stroke risk compared with a control cohort matched for age, sex, and index date. Cox regression analyses were performed to assess the hazard ratio (HR) of stroke and the corresponding 95% confidence interval (CI). Stroke-free probabilities were computed using the Kaplan-Meier method and differences between both cohorts were examined using the log-rank test. Results: We identified 29,961 patients with SAS and a control cohort of 119,844 subjects without SAS. The overall incidence of stroke in the SAS cohort was 37% higher compared to the non-SAS cohort (54.6 per 10,000 individual-years vs 39.8 per 10,000 individual-years). After controlling for sex and comorbidities, the SAS cohort exhibited a 19% higher risk for stroke compared to the control cohort (adjusted HR, 1.19 [95% CI, 1.09-1.30]). Women with SAS ages 35. years or younger had the highest stroke risk compared to older age groups of the same sex and their risk for stroke was relatively higher compared to their male counterparts. Conclusion: Women aged 35. years or younger with SAS have a higher stroke risk.

AB - Objective: Patients with sleep apnea syndrome (SAS) carry a higher stroke risk. The differential stroke risk between sex and among different age groups has not yet been specifically addressed in previous studies. Methods: Using a universal insurance claims database, we identified a large cohort of SAS patients from 1997 to 2010 and assessed the sex- and age-specific stroke risk compared with a control cohort matched for age, sex, and index date. Cox regression analyses were performed to assess the hazard ratio (HR) of stroke and the corresponding 95% confidence interval (CI). Stroke-free probabilities were computed using the Kaplan-Meier method and differences between both cohorts were examined using the log-rank test. Results: We identified 29,961 patients with SAS and a control cohort of 119,844 subjects without SAS. The overall incidence of stroke in the SAS cohort was 37% higher compared to the non-SAS cohort (54.6 per 10,000 individual-years vs 39.8 per 10,000 individual-years). After controlling for sex and comorbidities, the SAS cohort exhibited a 19% higher risk for stroke compared to the control cohort (adjusted HR, 1.19 [95% CI, 1.09-1.30]). Women with SAS ages 35. years or younger had the highest stroke risk compared to older age groups of the same sex and their risk for stroke was relatively higher compared to their male counterparts. Conclusion: Women aged 35. years or younger with SAS have a higher stroke risk.

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