High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients

Yi Ping Wang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Andy Sun, Julia Yu Fong Chang

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background/Purpose: Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Methods: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals. Results: We found that five (7.4%), 14 (20.6%), 34 (50.0%), 28 (41.2%), and nine (13.2%) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition. Conclusion: We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients.

Original languageEnglish
Pages (from-to)813-819
Number of pages7
JournalJournal of the Formosan Medical Association
Volume114
Issue number9
DOIs
Publication statusPublished - Sep 1 2015
Externally publishedYes

Fingerprint

Oral Submucous Fibrosis
Folic Acid Deficiency
Gastric Parietal Cells
Vitamin B 12
Antibodies
Serum
Folic Acid
Hemoglobins
Erythrocyte Indices
Iron
Anemia
Mouth Diseases
Macrocytic Anemia
Areca
Hematinics
Vitamin B 12 Deficiency
Pernicious Anemia
Thalassemia
Iron-Deficiency Anemias
Mastication

Keywords

  • Anemia
  • Folic acid deficiency
  • Gastric parietal cell antibody
  • Hemoglobin
  • Oral submucous fibrosis
  • Vitamin B<inf>12</inf> deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. / Wang, Yi Ping; Wu, Yang Che; Cheng, Shih Jung; Chen, Hsin Ming; Sun, Andy; Chang, Julia Yu Fong.

In: Journal of the Formosan Medical Association, Vol. 114, No. 9, 01.09.2015, p. 813-819.

Research output: Contribution to journalArticle

Wang, Yi Ping ; Wu, Yang Che ; Cheng, Shih Jung ; Chen, Hsin Ming ; Sun, Andy ; Chang, Julia Yu Fong. / High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 9. pp. 813-819.
@article{44f4e7fd5e704b278644ed514488b253,
title = "High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients",
abstract = "Background/Purpose: Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Methods: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals. Results: We found that five (7.4{\%}), 14 (20.6{\%}), 34 (50.0{\%}), 28 (41.2{\%}), and nine (13.2{\%}) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition. Conclusion: We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients.",
keywords = "Anemia, Folic acid deficiency, Gastric parietal cell antibody, Hemoglobin, Oral submucous fibrosis, Vitamin B<inf>12</inf> deficiency",
author = "Wang, {Yi Ping} and Wu, {Yang Che} and Cheng, {Shih Jung} and Chen, {Hsin Ming} and Andy Sun and Chang, {Julia Yu Fong}",
year = "2015",
month = "9",
day = "1",
doi = "10.1016/j.jfma.2015.05.011",
language = "English",
volume = "114",
pages = "813--819",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "9",

}

TY - JOUR

T1 - High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Chen, Hsin Ming

AU - Sun, Andy

AU - Chang, Julia Yu Fong

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background/Purpose: Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Methods: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals. Results: We found that five (7.4%), 14 (20.6%), 34 (50.0%), 28 (41.2%), and nine (13.2%) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition. Conclusion: We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients.

AB - Background/Purpose: Oral submucous fibrosis (OSF) is a chronic progressive scaring oral disease associated with areca quid chewing. This study evaluated whether OSF patients had anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Methods: The blood hemoglobin (Hb), iron, vitamin B12, and folic acid concentrations, mean corpuscular volume, and serum GPCA in 68 male OSF patients were measured and compared with the corresponding data in 136 age-matched male healthy control individuals. Results: We found that five (7.4%), 14 (20.6%), 34 (50.0%), 28 (41.2%), and nine (13.2%) of the 68 male OSF patients had Hb (< 13 g/dL), iron (≤ 70 μg/dL), vitamin B12 (≤ 450 pg/mL), and folic acid (≤ 6 ng/mL) deficiencies, and serum GPCA positivity, respectively. Furthermore, OSF patients had a significantly higher frequency of Hb (p = 0.006), vitamin B12 (p < 0.001), or folic acid (p < 0.001) deficiency and of serum GPCA positivity (p = 0.011) than healthy control participants. Of the five OSF patients with anemia, two had thalassemia trait, one had iron deficiency anemia, and two had macrocytic anemia (mean corpuscular volume ≥ 100 fL). In addition, of the nine OSF patients with serum GPCA positivity, six had vitamin B12 deficiency, five had folic acid deficiency, and two had iron deficiency. However, none of the nine GPCA-positive OSF patients had pernicious anemia based on the strict World Health Organization definition. Conclusion: We conclude that there are high frequencies of vitamin B12 and folic acid deficiencies and of serum GPCA positivity in our male OSF patients.

KW - Anemia

KW - Folic acid deficiency

KW - Gastric parietal cell antibody

KW - Hemoglobin

KW - Oral submucous fibrosis

KW - Vitamin B<inf>12</inf> deficiency

UR - http://www.scopus.com/inward/record.url?scp=84940453571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940453571&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2015.05.011

DO - 10.1016/j.jfma.2015.05.011

M3 - Article

VL - 114

SP - 813

EP - 819

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 9

ER -