High fat diet with a high monounsaturated fatty acid and polyunsaturated/saturated fatty acid ratio suppresses body fat accumulation and weight gain in obese hamsters

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Abstract

The aim of this study was to investigate the effect of a high fat diet with experimental oil consisting of 60% MUFAs (monounsaturated fatty acids) with a P/S ratio of 5 on fat deposition and lipid metabolism in obese hamsters. Hamsters were randomly assigned to a control group and a diet-induced obesity group for nine weeks. Then an additional eight-week experimental period began, during which obese hamsters were randomly divided into three groups and fed different amounts of the experimental oil mixture in their diets as follows: 5%, 15%, and 20% w/w (OB-M5, OB-M15, and OB-M20 groups, respectively). The results showed that the OB-M15 and OB-M20 groups had significantly lower blood cholesterol and higher insulin levels. Compared to the control group, the three obese groups exhibited higher hepatic fatty acid synthase activity; however, the acyl-CoA oxidase activities were also enhanced. Although dietary fat content differed, there were no differences in energy intake, final body weights, and epididymal fat weights among the four groups. These results suggest that regardless of whether the specimens had a high fat intake or not, dietary fat containing high MUFAs with a high P/S ratio had beneficial effects on maintaining blood lipid profiles and may not result in body fat accumulation in obese hamsters, possibly by promoting lipolytic enzyme activities.

Original languageEnglish
Article number1148
JournalNutrients
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 19 2017

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Monounsaturated Fatty Acids
High Fat Diet
high fat diet
monounsaturated fatty acids
Unsaturated Fatty Acids
hamsters
Cricetinae
body fat
Weight Gain
saturated fatty acids
Adipose Tissue
polyunsaturated fatty acids
Fatty Acids
fatty acid composition
weight gain
Body Weight
Dietary Fats
Fats
dietary fat
Oils

Keywords

  • Acyl-CoA oxidase
  • Diet-induced obesity
  • Fat accumulation
  • Monounsaturated fatty acids

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "High fat diet with a high monounsaturated fatty acid and polyunsaturated/saturated fatty acid ratio suppresses body fat accumulation and weight gain in obese hamsters",
abstract = "The aim of this study was to investigate the effect of a high fat diet with experimental oil consisting of 60{\%} MUFAs (monounsaturated fatty acids) with a P/S ratio of 5 on fat deposition and lipid metabolism in obese hamsters. Hamsters were randomly assigned to a control group and a diet-induced obesity group for nine weeks. Then an additional eight-week experimental period began, during which obese hamsters were randomly divided into three groups and fed different amounts of the experimental oil mixture in their diets as follows: 5{\%}, 15{\%}, and 20{\%} w/w (OB-M5, OB-M15, and OB-M20 groups, respectively). The results showed that the OB-M15 and OB-M20 groups had significantly lower blood cholesterol and higher insulin levels. Compared to the control group, the three obese groups exhibited higher hepatic fatty acid synthase activity; however, the acyl-CoA oxidase activities were also enhanced. Although dietary fat content differed, there were no differences in energy intake, final body weights, and epididymal fat weights among the four groups. These results suggest that regardless of whether the specimens had a high fat intake or not, dietary fat containing high MUFAs with a high P/S ratio had beneficial effects on maintaining blood lipid profiles and may not result in body fat accumulation in obese hamsters, possibly by promoting lipolytic enzyme activities.",
keywords = "Acyl-CoA oxidase, Diet-induced obesity, Fat accumulation, Monounsaturated fatty acids",
author = "Yang, {Suh Ching} and Lin, {Shyh Hsiang} and Chang, {Jung Su} and Chien, {Yi Wen}",
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AU - Yang, Suh Ching

AU - Lin, Shyh Hsiang

AU - Chang, Jung Su

AU - Chien, Yi Wen

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