High-dose daptomycin and fosfomycin treatment of a patient with endocarditis caused by daptomycin-nonsusceptible Staphylococcus aureus: Case report

Liang Yu Chen, Cheng Hsiung Huang, Shu Chen Kuo, Chen Yuan Hsiao, Mei Lin Lin, Fu Der Wang, Chang Phone Fung

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Background: Emergence of daptomycin-nonsusceptible (DNS) Staphylococcus aureus is a dreadful problem in the treatment of endocarditis. Few current therapeutic agents are effective for treating infections caused by DNS S. aureus.Case presentation: We describe the emergence of DNS S. aureus. in a patient with implantable cardioverter-defibrillator (ICD) device -related endocarditis who was priorily treated with daptomycin. Metastatic dissemination as osteomyelitis further complicated the management of endocarditis. The dilemma was successfully managed by surgical removal of the ICD device and combination antimicrobial therapy with high-dose daptomycin and fosfomycin.Conclusions: Surgical removal of intracardiac devices remains an important adjunctive measure in the treatment of endocarditis. Our case suggests that combination therapy is more favorable than single-agent therapy for infections caused by DNS S. aureus.

Original languageEnglish
Article number152
JournalBMC Infectious Diseases
Volume11
DOIs
Publication statusPublished - May 26 2011
Externally publishedYes

Keywords

  • Daptomycin-nonsusceptiblefosfomycin
  • ICD device-related endocarditis

ASJC Scopus subject areas

  • Infectious Diseases

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