High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

Cheng Huang Shen, Hsiao Yen Hsieh, Yuan Hung Wang, Syue Yi Chen, Chun Liang Tung, Jiann Der Wu, Chang TeLin Lin, Michael W Y Chan, Cheng Da Hsu, Deching Chang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.

Original languageEnglish
Pages (from-to)893-898
Number of pages6
JournalExperimental and Therapeutic Medicine
Volume1
Issue number5
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Dickkopf-1
  • Disease-free survival
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

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