High-density lipoprotein prevents organ damage in endotoxemia

Ru Ping Lee, Nien Tsung Lin, Yann Fen Chiou Chao, Chia-Chin Lin, Horng Jyh Harn, Hsing I. Chen

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.

Original languageEnglish
Pages (from-to)250-260
Number of pages11
JournalResearch in Nursing and Health
Volume30
Issue number3
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Animal model
  • Endotoxemia
  • Lipoprotein
  • Organ damage

ASJC Scopus subject areas

  • Nursing(all)

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