High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

Chih Pin Tsai, Yann Hung, Yi Hsin Chou, Dong Ming Huang, Jong Kai Hsiao, Chen Chang, Yao Chang Chen, Chung Yuan Mou

Research output: Contribution to journalArticlepeer-review

178 Citations (Scopus)

Abstract

The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalSmall
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

Keywords

  • Fluorescent probes
  • Imaging
  • Magnetic properties
  • Mesoporous materials
  • Nanorods

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Fingerprint

Dive into the research topics of 'High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe'. Together they form a unique fingerprint.

Cite this