High body mass index is not associated with coronary artery disease in angina patients with chronic kidney disease: A coronary angiography study

I. Wen Wu, Ming Jui Hung, Yung Chang Chen, Wen Jin Cherng, Mai Szu Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: High body mass index (BMI) is an established risk factor for coronary artery disease (CAD) in the general population. This relationship is less clear in CAD patients with different stages of chronic kidney disease (CKD) because many complications of CKD can cause malnutrition and low BMI. We studied the association of BMI and angiography-confirmed CAD in CKD patients. Methods: Thousand one hundred thirty-three patients admitted for coronary angiography was stratified by CKD classification. Demographic, clinical, hemodynamic, and angiographic findings were assessed. CKD patients (n = 980) were divided into angiographic CAD and non-CAD groups to compare traditional CAD risk factors. Patients with angiography-confirmed CAD (n = 496) were further analyzed for the association between BMI and CAD risk at different stages of CKD patients. Results: Mean BMI was 27.4 ± 4.1, 27.7 ± 4.0, 25.9 ± 3.5, 24.2 ± 3.8, 23.2 ± 3.0 and 23.8 ± 4.2 kg/m2 for normal renal function, stage I, II, III, IV, and V CKD patients, respectively. Male, old age, presence of CKD, diabetes, hypertension, smoking, and higher cholesterol had significant association with angiographic CAD in the CKD sub-cohort. Obesity was not related to CAD in the CKD sub-cohort. Using WHO category for obesity, mild CKD patients were more likely to be overweight (62.8%) and obese (72%); meanwhile, most moderate and severe CKD patients were not obese (P <0.05). Only 17.6% and 18.8% of moderate and severe CKD patients were obese (P <0.05), by Taiwan classification. Conclusion: High BMI was not associated with angiographic CAD in CKD patients with angina.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume336
Issue number4
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Coronary Angiography
Chronic Renal Insufficiency
Coronary Artery Disease
Body Mass Index
Angiography
Obesity
Taiwan
Malnutrition
Arteries
Hemodynamics
Smoking
Cholesterol
Demography

Keywords

  • Angiographic coronary artery disease
  • Body mass index
  • Cardiovascular disease
  • Chronic kidney disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

High body mass index is not associated with coronary artery disease in angina patients with chronic kidney disease : A coronary angiography study. / Wu, I. Wen; Hung, Ming Jui; Chen, Yung Chang; Cherng, Wen Jin; Wu, Mai Szu.

In: American Journal of the Medical Sciences, Vol. 336, No. 4, 10.2008, p. 303-308.

Research output: Contribution to journalArticle

@article{af1639b93efd4ad8814c2f281d204a67,
title = "High body mass index is not associated with coronary artery disease in angina patients with chronic kidney disease: A coronary angiography study",
abstract = "Background: High body mass index (BMI) is an established risk factor for coronary artery disease (CAD) in the general population. This relationship is less clear in CAD patients with different stages of chronic kidney disease (CKD) because many complications of CKD can cause malnutrition and low BMI. We studied the association of BMI and angiography-confirmed CAD in CKD patients. Methods: Thousand one hundred thirty-three patients admitted for coronary angiography was stratified by CKD classification. Demographic, clinical, hemodynamic, and angiographic findings were assessed. CKD patients (n = 980) were divided into angiographic CAD and non-CAD groups to compare traditional CAD risk factors. Patients with angiography-confirmed CAD (n = 496) were further analyzed for the association between BMI and CAD risk at different stages of CKD patients. Results: Mean BMI was 27.4 ± 4.1, 27.7 ± 4.0, 25.9 ± 3.5, 24.2 ± 3.8, 23.2 ± 3.0 and 23.8 ± 4.2 kg/m2 for normal renal function, stage I, II, III, IV, and V CKD patients, respectively. Male, old age, presence of CKD, diabetes, hypertension, smoking, and higher cholesterol had significant association with angiographic CAD in the CKD sub-cohort. Obesity was not related to CAD in the CKD sub-cohort. Using WHO category for obesity, mild CKD patients were more likely to be overweight (62.8{\%}) and obese (72{\%}); meanwhile, most moderate and severe CKD patients were not obese (P <0.05). Only 17.6{\%} and 18.8{\%} of moderate and severe CKD patients were obese (P <0.05), by Taiwan classification. Conclusion: High BMI was not associated with angiographic CAD in CKD patients with angina.",
keywords = "Angiographic coronary artery disease, Body mass index, Cardiovascular disease, Chronic kidney disease",
author = "Wu, {I. Wen} and Hung, {Ming Jui} and Chen, {Yung Chang} and Cherng, {Wen Jin} and Wu, {Mai Szu}",
year = "2008",
month = "10",
doi = "10.1097/MAJ.0b013e31816740e3",
language = "English",
volume = "336",
pages = "303--308",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - High body mass index is not associated with coronary artery disease in angina patients with chronic kidney disease

T2 - A coronary angiography study

AU - Wu, I. Wen

AU - Hung, Ming Jui

AU - Chen, Yung Chang

AU - Cherng, Wen Jin

AU - Wu, Mai Szu

PY - 2008/10

Y1 - 2008/10

N2 - Background: High body mass index (BMI) is an established risk factor for coronary artery disease (CAD) in the general population. This relationship is less clear in CAD patients with different stages of chronic kidney disease (CKD) because many complications of CKD can cause malnutrition and low BMI. We studied the association of BMI and angiography-confirmed CAD in CKD patients. Methods: Thousand one hundred thirty-three patients admitted for coronary angiography was stratified by CKD classification. Demographic, clinical, hemodynamic, and angiographic findings were assessed. CKD patients (n = 980) were divided into angiographic CAD and non-CAD groups to compare traditional CAD risk factors. Patients with angiography-confirmed CAD (n = 496) were further analyzed for the association between BMI and CAD risk at different stages of CKD patients. Results: Mean BMI was 27.4 ± 4.1, 27.7 ± 4.0, 25.9 ± 3.5, 24.2 ± 3.8, 23.2 ± 3.0 and 23.8 ± 4.2 kg/m2 for normal renal function, stage I, II, III, IV, and V CKD patients, respectively. Male, old age, presence of CKD, diabetes, hypertension, smoking, and higher cholesterol had significant association with angiographic CAD in the CKD sub-cohort. Obesity was not related to CAD in the CKD sub-cohort. Using WHO category for obesity, mild CKD patients were more likely to be overweight (62.8%) and obese (72%); meanwhile, most moderate and severe CKD patients were not obese (P <0.05). Only 17.6% and 18.8% of moderate and severe CKD patients were obese (P <0.05), by Taiwan classification. Conclusion: High BMI was not associated with angiographic CAD in CKD patients with angina.

AB - Background: High body mass index (BMI) is an established risk factor for coronary artery disease (CAD) in the general population. This relationship is less clear in CAD patients with different stages of chronic kidney disease (CKD) because many complications of CKD can cause malnutrition and low BMI. We studied the association of BMI and angiography-confirmed CAD in CKD patients. Methods: Thousand one hundred thirty-three patients admitted for coronary angiography was stratified by CKD classification. Demographic, clinical, hemodynamic, and angiographic findings were assessed. CKD patients (n = 980) were divided into angiographic CAD and non-CAD groups to compare traditional CAD risk factors. Patients with angiography-confirmed CAD (n = 496) were further analyzed for the association between BMI and CAD risk at different stages of CKD patients. Results: Mean BMI was 27.4 ± 4.1, 27.7 ± 4.0, 25.9 ± 3.5, 24.2 ± 3.8, 23.2 ± 3.0 and 23.8 ± 4.2 kg/m2 for normal renal function, stage I, II, III, IV, and V CKD patients, respectively. Male, old age, presence of CKD, diabetes, hypertension, smoking, and higher cholesterol had significant association with angiographic CAD in the CKD sub-cohort. Obesity was not related to CAD in the CKD sub-cohort. Using WHO category for obesity, mild CKD patients were more likely to be overweight (62.8%) and obese (72%); meanwhile, most moderate and severe CKD patients were not obese (P <0.05). Only 17.6% and 18.8% of moderate and severe CKD patients were obese (P <0.05), by Taiwan classification. Conclusion: High BMI was not associated with angiographic CAD in CKD patients with angina.

KW - Angiographic coronary artery disease

KW - Body mass index

KW - Cardiovascular disease

KW - Chronic kidney disease

UR - http://www.scopus.com/inward/record.url?scp=56049089865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56049089865&partnerID=8YFLogxK

U2 - 10.1097/MAJ.0b013e31816740e3

DO - 10.1097/MAJ.0b013e31816740e3

M3 - Article

C2 - 18854671

AN - SCOPUS:56049089865

VL - 336

SP - 303

EP - 308

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 4

ER -