High ambient Cladosporium spores were associated with reduced lung function in schoolchildren in a longitudinal study

Bing Yu Chen, H. Jasmine Chao, Chang fu Wu, Ho Kim, Yasushi Honda, Yue Leon Guo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: In our previous longitudinal study, we found that exposure to current levels of ambient total fungal spores was related to a reduction of childhood lung function. However, the biological properties of various taxa of fungal spores varied greatly, as well as their health effects. In this study, we aimed to determine whether any specific fungal spores were responsible for observed changes in lung function. Methods: Measurement of lung function was conducted for 100 elementary and middle-school students on 5-10 occasions from October 2007 to November 2009 in New Taipei City, Taiwan. During the week of each lung function measurement, continuous daily concentrations of fungal spores were measured from Sunday to Saturday. The counts of fungal spores belonging to specific taxa were identified. A mixed-effect model with repeated measurements was used to analyze the association of lung function and exposure to each specific taxon of fungal spores. Forward stepwise regression was applied to determine which specific fungal spores were the most closely related to lung function changes. The non-linear relationship was examined using a generalized additive model. The piecewise linear regression was then applied to determine the threshold value. Results: A total of 824 measurements were obtained from 100 participants. Among all the species of fungal spores, only Cladosporium spores were found to be negatively associated with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) one day later. This association was stronger than the one between the total spore counts and lung function. The threshold of exposure where lung function effect became observable was approximately 1500spores/m3. Conclusion: This study showed that ambient Cladosporium was most strongly associated with the observed lung function changes among schoolchildren. Replication of these preliminary findings in other geographic areas with different populations would be warranted.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalScience of the Total Environment
Volume481
Issue number1
DOIs
Publication statusPublished - May 15 2014

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spore
Association reactions
measurement method
Linear regression
Health
student
Students
exposure
effect

Keywords

  • Children
  • Cladosporium
  • Forced expiratory volume in one second
  • Forced vital capacity
  • Fungal spores
  • Lung function

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering

Cite this

High ambient Cladosporium spores were associated with reduced lung function in schoolchildren in a longitudinal study. / Chen, Bing Yu; Jasmine Chao, H.; Wu, Chang fu; Kim, Ho; Honda, Yasushi; Guo, Yue Leon.

In: Science of the Total Environment, Vol. 481, No. 1, 15.05.2014, p. 370-376.

Research output: Contribution to journalArticle

Chen, Bing Yu ; Jasmine Chao, H. ; Wu, Chang fu ; Kim, Ho ; Honda, Yasushi ; Guo, Yue Leon. / High ambient Cladosporium spores were associated with reduced lung function in schoolchildren in a longitudinal study. In: Science of the Total Environment. 2014 ; Vol. 481, No. 1. pp. 370-376.
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