High agatston calcium score of intracranial carotid artery: A significant risk factor for cognitive impairment

Hung Wen Kao, Michelle Liou, Hsiao Wen Chung, Hua Shan Liu, Ping Huei Tsai, Shih Wei Chiang, Ming Chung Chou, Giia Sheun Peng, Guo Shu Huang, Hsian He Hsu, Cheng Yu Chen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function. In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P

Original languageEnglish
Pages (from-to)e1546
JournalMedicine (United States)
Volume94
Issue number39
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Medicine(all)

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