Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment

Kuan Ting Lee, Yu Jen Lu, Shao Chieh Chiu, Wen Chi Chang, Er Yuan Chuang, Shih Yuan Lu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A selective colon cancer cell therapy was effectively achieved with catalase-mediated intra-cellular heterogeneous Fenton reactions triggered by cellular uptake of SnFe2O4 nanocrystals. The treatment was proven effective for eradicating colon cancer cells, whereas was benign to normal colon cells, thus effectively realizing the selective colon cancer cell therapeutics. Cancer cells possess much higher innate hydrogen peroxide (H2O2) but much lower catalase levels than normal cells. Catalase, an effective H2O2 scavenger, prevented attacks on cells by reactive oxygen species induced from H2O2. The above intrinsic difference between cancer and normal cells was utilized to achieve selective colon cancer cell eradication through endocytosing efficient heterogeneous Fenton catalysts to trigger the formation of highly reactive oxygen species from H2O2. In this paper, SnFe2O4 nanocrystals, a newly noted outstanding paramagnetic heterogeneous Fenton catalyst, have been verified an effective selective colon cancerous cell treatment reagent of satisfactory blood compatibility.

Original languageEnglish
Article number16580
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Colon
Colonic Neoplasms
Catalase
Therapeutics
Nanoparticles
Reactive Oxygen Species
Cell- and Tissue-Based Therapy
Endocytosis
Hydrogen Peroxide
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment. / Lee, Kuan Ting; Lu, Yu Jen; Chiu, Shao Chieh; Chang, Wen Chi; Chuang, Er Yuan; Lu, Shih Yuan.

In: Scientific Reports, Vol. 8, No. 1, 16580, 01.12.2018.

Research output: Contribution to journalArticle

Lee, Kuan Ting ; Lu, Yu Jen ; Chiu, Shao Chieh ; Chang, Wen Chi ; Chuang, Er Yuan ; Lu, Shih Yuan. / Heterogeneous Fenton Reaction Enabled Selective Colon Cancerous Cell Treatment. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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