TY - JOUR
T1 - Heterogeneous expression of potassium currents and pacemaker currents potentially regulates arrhythmogenesis of pulmonary vein cardiomyocytes
AU - Chen, Yao Chang
AU - Pan, Nan Hung
AU - Cheng, Chen Chuan
AU - Higa, Satoshi
AU - Chen, Yi Jen
AU - Chen, Shih Ann
PY - 2009/9
Y1 - 2009/9
N2 - Potassium Currents on Pulmonary Veins' Arrhythmogenesis. Introduction: The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. Methods: Whole-cell patch clamp was used to investigate the action potentials, transient outward currents (I to), sustained outward potassium currents (IKsus), rapid delayed rectifier potassium currents (IKr), inward rectifier potassium current (IK1), pacemaker currents (If), and transient inward currents in isolated rabbit PV single fast (≥2.5 Hz) and slow (to and IK1, and larger If but with similar IKsus, IKr, and transient inward currents. However, only few fast (2/34) and slow (1/23) PV pacemaker cardiomyocytes contained barium-sensitive hyperpolarization-activated time-dependent current (I KH). Conclusions and Implications: The fast and slow PV pacemaker had different electrophysiological characteristics. Ito, IK1, and If may regulate the beating rates of PV pacemaker cardiomyocytes. (J Cardiovasc Electrophysiol, Vol. 20, pp. 1039-1045)
AB - Potassium Currents on Pulmonary Veins' Arrhythmogenesis. Introduction: The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. Methods: Whole-cell patch clamp was used to investigate the action potentials, transient outward currents (I to), sustained outward potassium currents (IKsus), rapid delayed rectifier potassium currents (IKr), inward rectifier potassium current (IK1), pacemaker currents (If), and transient inward currents in isolated rabbit PV single fast (≥2.5 Hz) and slow (to and IK1, and larger If but with similar IKsus, IKr, and transient inward currents. However, only few fast (2/34) and slow (1/23) PV pacemaker cardiomyocytes contained barium-sensitive hyperpolarization-activated time-dependent current (I KH). Conclusions and Implications: The fast and slow PV pacemaker had different electrophysiological characteristics. Ito, IK1, and If may regulate the beating rates of PV pacemaker cardiomyocytes. (J Cardiovasc Electrophysiol, Vol. 20, pp. 1039-1045)
KW - Atrial Fibrillation
KW - Pacemaker Currents
KW - Potassium Currents
KW - Pulmonary Vein
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U2 - 10.1111/j.1540-8167.2009.01480.x
DO - 10.1111/j.1540-8167.2009.01480.x
M3 - Article
C2 - 19473300
AN - SCOPUS:69249191508
VL - 20
SP - 1039
EP - 1045
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
SN - 1045-3873
IS - 9
ER -