Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng; Chiung Fang Chang; Wen Juei Jeng; I. Shyan Sheen; Chi Juei Jeng

doi:10.1016/j.critrevonc.2015.01.009

Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng, Chiung Fang Chang, Wen Juei Jeng, I. Shyan Sheen, Chi Juei Jeng

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

Original language	English
Pages (from-to)	337-347
Number of pages	11
Journal	Critical Reviews in Oncology/Hematology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/j.critrevonc.2015.01.009
Publication status	Published - Jun 1 2015
Externally published	Yes

Keywords

Angiogenesis
Cancer stem cells
Genetic variation
Hepatocellular carcinoma
Heterogeneity
Invasion
Signaling pathway
Tumor microenvironment

ASJC Scopus subject areas

Hematology
Oncology

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@article{7007cf5fb3e74393b9c58a82cf8e5453,

title = "Heterogeneity of hepatocellular carcinoma contributes to cancer progression",

abstract = "Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.",

keywords = "Angiogenesis, Cancer stem cells, Genetic variation, Hepatocellular carcinoma, Heterogeneity, Invasion, Signaling pathway, Tumor microenvironment",

author = "Jeng, {Kuo Shyang} and Chang, {Chiung Fang} and Jeng, {Wen Juei} and Sheen, {I. Shyan} and Jeng, {Chi Juei}",

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T1 - Heterogeneity of hepatocellular carcinoma contributes to cancer progression

AU - Jeng, Kuo Shyang

AU - Chang, Chiung Fang

AU - Jeng, Wen Juei

AU - Sheen, I. Shyan

AU - Jeng, Chi Juei

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

AB - Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

KW - Angiogenesis

KW - Cancer stem cells

KW - Genetic variation

KW - Hepatocellular carcinoma

KW - Heterogeneity

KW - Invasion

KW - Signaling pathway

KW - Tumor microenvironment

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