Heterogeneity of hepatocellular carcinoma contributes to cancer progression

Kuo Shyang Jeng, Chiung Fang Chang, Wen Juei Jeng, I. Shyan Sheen, Chi Juei Jeng

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)


Hepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment.

Original languageEnglish
Pages (from-to)337-347
Number of pages11
JournalCritical Reviews in Oncology/Hematology
Issue number3
Publication statusPublished - Jun 1 2015
Externally publishedYes


  • Angiogenesis
  • Cancer stem cells
  • Genetic variation
  • Hepatocellular carcinoma
  • Heterogeneity
  • Invasion
  • Signaling pathway
  • Tumor microenvironment

ASJC Scopus subject areas

  • Hematology
  • Oncology


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