Heterogeneity in radiosensitivity of human diploid fibroblasts from keloids and normal skins

Shiuh Ma, Rong Hwang Fang, Wushou P. Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Colony-forming ability was employed in evaluating the susceptibility to in vitro gamma ionizing radiation in human diploid skin fibroblasts (HDF). Twelve pairs of HDF, each composed of fibroblasts from excised keloid lesion and local normal skin tissue as its control, were studied in patients with clinically persistent keloids. Parameters of radiosensitivity, both D0 and D10, and growth kinetics were examined. The radiosensitivity in three of the 12 keloids (25%) were demonstrated significantly increased than their counterpart controls, even though no difference in growth kinetics in between. Moreover, a broad range in the radiosensitivity of fibroblast cells was demonstrated and it is suggested that there is a great heterogeneity of cellular response to radiation in HDF.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalCell Biology International
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 1996
Externally publishedYes

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Keywords

  • Fibroblasts
  • Heterogeneity
  • Keloids
  • Radiosensitivity

ASJC Scopus subject areas

  • Cell Biology

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