Herniated blastomere following chemically assisted hatching may result in monozygotic twins

Tzong Chyi Sheen, Su-Ru Chen, Heng Kien Au, Yi Yi Chien, Ko Yi Wu, Chii Ruey Tzeng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalFertility and Sterility
Volume75
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Blastomeres
Monozygotic Twins
Embryonic Structures
Zona Pellucida
Herpes Zoster
Triplet Pregnancy
Pregnancy Outcome
Medical Schools
Teaching Hospitals
Outcome Assessment (Health Care)
Incidence
Research

Keywords

  • Assisted hatching
  • Blastomere herniation
  • Monozygotic twins

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Herniated blastomere following chemically assisted hatching may result in monozygotic twins. / Sheen, Tzong Chyi; Chen, Su-Ru; Au, Heng Kien; Chien, Yi Yi; Wu, Ko Yi; Tzeng, Chii Ruey.

In: Fertility and Sterility, Vol. 75, No. 2, 2001, p. 442-444.

Research output: Contribution to journalArticle

@article{1422e7d831124784b044948812b2cc7c,
title = "Herniated blastomere following chemically assisted hatching may result in monozygotic twins",
abstract = "Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.",
keywords = "Assisted hatching, Blastomere herniation, Monozygotic twins",
author = "Sheen, {Tzong Chyi} and Su-Ru Chen and Au, {Heng Kien} and Chien, {Yi Yi} and Wu, {Ko Yi} and Tzeng, {Chii Ruey}",
year = "2001",
doi = "10.1016/S0015-0282(00)01710-6",
language = "English",
volume = "75",
pages = "442--444",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Herniated blastomere following chemically assisted hatching may result in monozygotic twins

AU - Sheen, Tzong Chyi

AU - Chen, Su-Ru

AU - Au, Heng Kien

AU - Chien, Yi Yi

AU - Wu, Ko Yi

AU - Tzeng, Chii Ruey

PY - 2001

Y1 - 2001

N2 - Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

AB - Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

KW - Assisted hatching

KW - Blastomere herniation

KW - Monozygotic twins

UR - http://www.scopus.com/inward/record.url?scp=0035140784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035140784&partnerID=8YFLogxK

U2 - 10.1016/S0015-0282(00)01710-6

DO - 10.1016/S0015-0282(00)01710-6

M3 - Article

C2 - 11172856

AN - SCOPUS:0035140784

VL - 75

SP - 442

EP - 444

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 2

ER -