Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers

Yu Chen S.H. Yang, Zi Lin Li, Ya Jung Shih, James A. Bennett, Jaqueline Whang-Peng, Hung Yun Lin, Paul J. Davis, Kuan Wang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties.

Original languageEnglish
Article number2979
JournalNutrients
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2019

Fingerprint

Herbal Medicine
herbal medicines
obesity
Obesity
death
Ligands
neoplasms
L-thyroxine
Hormones
hormones
Neoplasms
cytokines
Programmed Cell Death 1 Receptor
tumor necrosis factors
resveratrol
Cytokines
heart diseases
steroid hormones
leptin
Heart Neoplasms

Keywords

  • Anoectochilus formosanus hayata
  • Curcumin
  • PD-L1
  • Resveratrol
  • Steroid hormone
  • Thyroid hormone

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers. / Yang, Yu Chen S.H.; Li, Zi Lin; Shih, Ya Jung; Bennett, James A.; Whang-Peng, Jaqueline; Lin, Hung Yun; Davis, Paul J.; Wang, Kuan.

In: Nutrients, Vol. 11, No. 12, 2979, 12.2019.

Research output: Contribution to journalReview article

Yang, Yu Chen S.H. ; Li, Zi Lin ; Shih, Ya Jung ; Bennett, James A. ; Whang-Peng, Jaqueline ; Lin, Hung Yun ; Davis, Paul J. ; Wang, Kuan. / Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers. In: Nutrients. 2019 ; Vol. 11, No. 12.
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abstract = "Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties.",
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