Her-2/neu overexpression is associated with thrombospondin-1-related angiogenesis and thrombospondin-1-unrelated lymphangiogenesis in breast cancer

Ming Chuan Hong, Cheng Yu Long, Yu Feng Tian, Ming Ping Wu

Research output: Contribution to journalArticle

1 Citation (Scopus)


Introduction: Her-2/. neu overexpression is linked to poor prognosis and is a significant predictor of the response to trastuzumab (i.e., herceptin) therapy in breast cancer patients. Her-2/. neu promotes angiogenesis with thrombospondin-1 (TSP-1) as a mediator in breast cancer development and progression. However, the clinical quantitative evaluation of Her-2/. neu and specified localization of TSP-1 are currently lacking. Materials and methods: In this study, immunohistochemistry was performed to elucidate the invivo relationships between Her-2/. neu and TSP-1 expression, angiogenesis, and lymphangiogenesis in breast cancer. Based on immunohistochemical staining for anti-Her-2/. neu and related quantitative scoring of tumor cells, 28 individuals with high Her-2/. Neu expression (i.e., with a score of ≥2.0) were recruited into the study group. Another 28 individuals with low Her-2/. neu (i.e., with a score of

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalGynecology and Minimally Invasive Therapy
Issue number4
Publication statusPublished - Nov 2013



  • Angiogenesis
  • Automated cellular imaging system
  • Breast cancer
  • Her-2/neu
  • Lymphangiogenesis
  • Thrombospondin-1
  • Tumor-stroma interaction

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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