Hepatotoxicity induced by clozapine: A case report and review of literature

Ana Isabel Wu Chou, Mong Liang Lu, Winston W. Shen

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two to three times greater than normal. Though elevations in liver function tests are often transient and asymptomatic, there are many reported cases of clozapine-induced hepatotoxicity, with damage to the liver, involvement of multiple organs, and even fulminant liver failure arising with moderate clozapine doses. This case report describes a Chinese woman who developed hepatotoxicity on a low dose of clozapine, and reviews the relevant literature.

Original languageEnglish
Pages (from-to)1585-1587
Number of pages3
JournalNeuropsychiatric Disease and Treatment
Volume10
DOIs
Publication statusPublished - Aug 26 2014
Externally publishedYes

Keywords

  • Antipsychotic adverse effects
  • Drug-induced liver injury
  • Hepatitis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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