Hepatoprotective effects of Taiwan folk medicine

wedelia chinensis on three hepatotoxin-induced hepatotoxicity.

Song-Chow Lin, C. C. Lin, Y. H. Lin, S. J. Shyuu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The hepatoprotective effects of a Taiwanese crude herb, Hwang-hua-mih-tsay (Wedelia chinensis (Osbeck) Merr.), were investigated. Acute hepatitis was induced by three hepatotoxins: carbon tetrachloride and acetaminophen in mice, and D(+)-galactosamine in rats. After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered. These serological observations were confirmed by histopathological examinations. A microscopic examination of the liver showed a marked improvement in groups receiving W. chinensis. In order to further confirm the hepatoprotective effect of W. chinensis, all pharmacological and histopathological effects were compared with Bupleurum chinense DC. (family Umbelliferae), a well documented antihepatotoxicity herb. It was concluded that W. chinensis has a definite hepatoprotective effect against liver injuries.

Original languageEnglish
Pages (from-to)155-168
Number of pages14
JournalAmerican Journal of Chinese Medicine
Volume22
Issue number2
Publication statusPublished - 1994

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Wedelia
Traditional Medicine
Transaminases
Taiwan
Glutamic Acid
Bupleurum
Apiaceae
Galactosamine
Carbon Tetrachloride
Liver
Acetaminophen
Hepatitis
Pharmacology
Wounds and Injuries
Serum
Therapeutics

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Hepatoprotective effects of Taiwan folk medicine : wedelia chinensis on three hepatotoxin-induced hepatotoxicity. / Lin, Song-Chow; Lin, C. C.; Lin, Y. H.; Shyuu, S. J.

In: American Journal of Chinese Medicine, Vol. 22, No. 2, 1994, p. 155-168.

Research output: Contribution to journalArticle

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