Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Guan Jhong Huang, Jeng Shyan Deng, Shyh Shyun Huang, Chao Ying Lee, Wen Chi Hou, Sheng Yang Wang, Ping Jyun Sung, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4. Pretreatment with TR1 and TR2 prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and liver lipid peroxides in CCl4-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)], nitric oxide (NO) production, and tumour necrosis factor-alpha (TNF-α) were decreased after the treatment with TR1 and TR2 in CCl 4-treated mice. Western blotting revealed that TR1 and TR2 significantly decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions and increased the expression of cytochrome P4502E1 (CYP2E1) in CCl4-treated mice. Therefore, we speculate that TR1 and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.

Original languageEnglish
Pages (from-to)3020-3027
Number of pages8
JournalFood Chemistry
Volume141
Issue number3
DOIs
Publication statusPublished - 2013

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Antrodia
Taiwanofungus camphoratus
hepatoprotective effect
Liver
animal models
liver
acids
mice
Wounds and Injuries
Antioxidants
Carbon Tetrachloride
Lipid Peroxides
Nitric Oxide Synthase Type II
Cyclooxygenase 2
Cytochromes
Glutathione Peroxidase
Aspartate Aminotransferases
Alanine Transaminase
Catalase
carbon tetrachloride

Keywords

  • Anti-inflammation
  • Antrodia camphorata
  • Dehydroeburicoic acid
  • Eburicoic acid
  • NO
  • TNF-α

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. / Huang, Guan Jhong; Deng, Jeng Shyan; Huang, Shyh Shyun; Lee, Chao Ying; Hou, Wen Chi; Wang, Sheng Yang; Sung, Ping Jyun; Kuo, Yueh Hsiung.

In: Food Chemistry, Vol. 141, No. 3, 2013, p. 3020-3027.

Research output: Contribution to journalArticle

Huang, Guan Jhong ; Deng, Jeng Shyan ; Huang, Shyh Shyun ; Lee, Chao Ying ; Hou, Wen Chi ; Wang, Sheng Yang ; Sung, Ping Jyun ; Kuo, Yueh Hsiung. / Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. In: Food Chemistry. 2013 ; Vol. 141, No. 3. pp. 3020-3027.
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