Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury

Guan Jhong Huang, Jeng Shyan Deng, Shyh Shyun Huang, Chao Ying Lee, Wen Chi Hou, Sheng Yang Wang, Ping Jyun Sung, Yueh Hsiung Kuo

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44 Citations (Scopus)

Abstract

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4. Pretreatment with TR1 and TR2 prevented the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and liver lipid peroxides in CCl4-treated mice. The activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)], nitric oxide (NO) production, and tumour necrosis factor-alpha (TNF-α) were decreased after the treatment with TR1 and TR2 in CCl 4-treated mice. Western blotting revealed that TR1 and TR2 significantly decreased inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions and increased the expression of cytochrome P4502E1 (CYP2E1) in CCl4-treated mice. Therefore, we speculate that TR1 and TR2 protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms.

Original languageEnglish
Pages (from-to)3020-3027
Number of pages8
JournalFood Chemistry
Volume141
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Anti-inflammation
  • Antrodia camphorata
  • Dehydroeburicoic acid
  • Eburicoic acid
  • NO
  • TNF-α

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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