Hepatocellular Carcinoma With Presentation of Budd-Chiari Syndrome

Wei Yu Kao, Hung Hsu Hung, Hsueh Chieh Lu, Han Chieh Lin, Jaw Ching Wu, Shou Dong Lee, Chien Wei Su

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Budd-Chiari syndrome is defined as hepatic venous outflow obstruction at any level from the small hepatic veins to the junction of the inferior vena cava and the right atrium independent of the underlying disease. We report here a 40-year-old male patient who complained of abdominal fullness and bilateral lower leg edema for 1 month. A physical examination disclosed bilateral lower leg edema. Abdominal sonography revealed a small amount of ascites with thrombosis of the inferior vena cava and right hepatic vein. Viral hepatitis marker tests showed positive hepatitis B surface antigen. Tumor markers showed elevated serum a-fetoprotein levels. Computed tomography and magnetic resonance imaging confirmed hepatocellular carcinoma with inferior vena cava and right hepatic vein thrombosis. Therefore, hepatocellular carcinoma with Budd-Chiari syndrome was diagnosed. The patient was treated with intravenous heparin, which was then changed to oral warfarin. Although it is relatively rare, clinicians should be aware of hepatocellular carcinoma with Budd-Chiari syndrome when leg edema occurs without hypoalbuminemia in patients with chronic hepatitis B, because these patients are in the high-risk group for developing hepatocellular carcinoma. Regular follow-up of chronic hepatitis B, including biochemical and sonography surveillance, should be performed.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalJournal of the Chinese Medical Association
Volume73
Issue number2
DOIs
Publication statusPublished - Feb 1 2010
Externally publishedYes

Fingerprint

Budd-Chiari Syndrome
Hepatocellular Carcinoma
Inferior Vena Cava
Edema
Leg
Hepatic Veins
Chronic Hepatitis B
Ultrasonography
Fetal Proteins
Hypoalbuminemia
Warfarin
Tumor Biomarkers
Hepatitis B Surface Antigens
Heart Atria
Ascites
Hepatitis
Physical Examination
Heparin
Thrombosis
Biomarkers

Keywords

  • Budd-Chiari syndrome
  • hepatitis B virus
  • hepatocellular carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatocellular Carcinoma With Presentation of Budd-Chiari Syndrome. / Kao, Wei Yu; Hung, Hung Hsu; Lu, Hsueh Chieh; Lin, Han Chieh; Wu, Jaw Ching; Lee, Shou Dong; Su, Chien Wei.

In: Journal of the Chinese Medical Association, Vol. 73, No. 2, 01.02.2010, p. 93-96.

Research output: Contribution to journalArticle

Kao, Wei Yu ; Hung, Hung Hsu ; Lu, Hsueh Chieh ; Lin, Han Chieh ; Wu, Jaw Ching ; Lee, Shou Dong ; Su, Chien Wei. / Hepatocellular Carcinoma With Presentation of Budd-Chiari Syndrome. In: Journal of the Chinese Medical Association. 2010 ; Vol. 73, No. 2. pp. 93-96.
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