Hepatitis C virus infection in patients with primary biliary cirrhosis

Hsuan-Wei Chen, Hsin-Hung Huang, Ching-Huang Lai, Wei-En Chang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalAnnals of Hepatology
Volume12
Issue number1
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Biliary Liver Cirrhosis
Virus Diseases
Hepacivirus
End Stage Liver Disease
Fibrosis
Liver Cirrhosis
Medical Records

Keywords

  • Child-Pugh score
  • Cirrhosis
  • MELD score
  • alanine aminotransferase
  • albumin
  • aspartate aminotransferase
  • bilirubin
  • creatinine
  • interferon
  • ribavirin
  • virus RNA
  • adult
  • age
  • aged
  • article
  • ascites
  • autoimmune disease
  • bleeding
  • Child Pugh score
  • clinical article
  • comorbidity
  • controlled study
  • death
  • disease severity
  • female
  • follow up
  • hepatitis C
  • human
  • international normalized ratio
  • liver cell carcinoma
  • liver cirrhosis
  • male
  • medical record review
  • Model For End Stage Liver Disease Score
  • neoplasm
  • primary biliary cirrhosis
  • survival rate
  • virus load
  • biliary cirrhosis
  • case control study
  • disease course
  • middle aged
  • prognosis
  • retrospective study
  • severity of illness index
  • Adult
  • Aged
  • Case-Control Studies
  • Disease Progression
  • Female
  • Hepatitis C
  • Humans
  • Liver Cirrhosis, Biliary
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Severity of Illness Index

Cite this

Chen, H-W., Huang, H-H., Lai, C-H., Chang, W-E., Shih, Y-L., Chang, W-K., ... Chu, H-C. (2013). Hepatitis C virus infection in patients with primary biliary cirrhosis. Annals of Hepatology, 12(1), 78-84.

Hepatitis C virus infection in patients with primary biliary cirrhosis. / Chen, Hsuan-Wei; Huang, Hsin-Hung; Lai, Ching-Huang; Chang, Wei-En; Shih, Yu-Lueng; Chang, Wei-Kuo; Hsieh, Tsai-Yuan; Chu, Heng-Cheng.

In: Annals of Hepatology, Vol. 12, No. 1, 2013, p. 78-84.

Research output: Contribution to journalArticle

Chen, H-W, Huang, H-H, Lai, C-H, Chang, W-E, Shih, Y-L, Chang, W-K, Hsieh, T-Y & Chu, H-C 2013, 'Hepatitis C virus infection in patients with primary biliary cirrhosis', Annals of Hepatology, vol. 12, no. 1, pp. 78-84.
Chen H-W, Huang H-H, Lai C-H, Chang W-E, Shih Y-L, Chang W-K et al. Hepatitis C virus infection in patients with primary biliary cirrhosis. Annals of Hepatology. 2013;12(1):78-84.
Chen, Hsuan-Wei ; Huang, Hsin-Hung ; Lai, Ching-Huang ; Chang, Wei-En ; Shih, Yu-Lueng ; Chang, Wei-Kuo ; Hsieh, Tsai-Yuan ; Chu, Heng-Cheng. / Hepatitis C virus infection in patients with primary biliary cirrhosis. In: Annals of Hepatology. 2013 ; Vol. 12, No. 1. pp. 78-84.
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title = "Hepatitis C virus infection in patients with primary biliary cirrhosis",
abstract = "Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8{\%}) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.",
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author = "Hsuan-Wei Chen and Hsin-Hung Huang and Ching-Huang Lai and Wei-En Chang and Yu-Lueng Shih and Wei-Kuo Chang and Tsai-Yuan Hsieh and Heng-Cheng Chu",
note = "被引用次數:1 Export Date: 22 March 2016 通訊地址: Chu, H.-C.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan; 電子郵件: chu5583@ms55.hinet.net 化學物質/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; bilirubin, 18422-02-1, 635-65-4; creatinine, 19230-81-0, 60-27-5; ribavirin, 36791-04-5 出資詳情: NSC94-2314-B-016-047, National Science Council Taiwan 參考文獻: Kaplan, M.M., Gershwin, M.E., Primary biliary cirrhosis (2006) N Engl J Med, 353, pp. 1261-1273; Myers, R.P., Shaheen, A.A., Fong, A., Burak, K.W., Wan, A., Swain, M.G., Hilsden, R.J., Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: A population-based study (2009) Hepatology, 50, p. 1884; Kumagi, T., Heathcote, E.J., Primary biliary cirrhosis (2008) Orphanet J Rare Dis, 3, p. 1; Poupon, R.E., Lindor, K.D., Par{\'e}s, A., Chazouilleres, O., Poupon, R., Heathcote, E.J., Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis (2003) J Hepatol, 39, pp. 12-16; Davis, G.L., Albright, J.E., Cook, S.F., Rosenberg, D.M., Projecting future complications of chronic hepatitis C in the United-States (2003) Liver Transpl, 9, pp. 331-338; Haddad, J., Deny, P., Munz-Gotheil, C., Ambrosini, J.C., Trinchet, J.C., Pateron, D., Mal, F., Lymphocytic sialadenitis of Sj{\"o}gren's syndrome associated with chronic hepatitis C virus liver disease (1992) Lancet, 339, pp. 321-323; Marcellin, P., Pouteau, M., Benhamou, J.P., Hepatitis C virus infection, alpha interferon therapy and thyroid dysfunction (1995) J Hepatol, 22, pp. 364-369; Lunel, F., Cacoub, P., Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection (1999) J Hepatol, 31, pp. 210-216; Floreani, A., Baragiotta, A., Leone, M.G., Baldo, V., Naccarato, R., Primary biliary cirrhosis and hepatitis C virus infection (2003) Am J Gastroenterol, 98, pp. 2757-2762; Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., Model for end-stage liver disease (MELD) and allocation of donor livers (2003) Gastroenterology, 124, pp. 91-96; Housset, C., Hirschauer, C., Degos, F., False positive anti-HCV in biliary cirrhosis (1991) Lancet, 114, p. 252. , (Letter); Fusconi, M., Lenzi, M., Ballardini, G., Miniero, R., Cassani, F., Zauli, D., Bianchi, F.B., Anti-HCV testing in autoimmune hepatitis and primary biliary cirrhosis (1990) Lancet, 336, p. 823; Imada, J., Hoshino, H., Nishimura, D., Morita, K., Yoshida, N., Katada, N., Sano, H., Case report: Multiple cancers: Hepatocellular carcinoma and adenocarcinomas of the common bile duct and the gall-bladder in a woman with primary biliary cirrhosis (1996) J Gastroenterol Hepatol, 11, pp. 546-550; Hoso, M., Nakanuma, Y., Kawano, M., Oda, K., Tsuneyama, K., van de water, J., Gershiwin, M.E., Granulomatous cholangitis in chronic hepatitis C: A new diagnostic problem in liver pathology (1996) Pathol Int, 46, pp. 301-305; Mouelhi, L., Chaieb, M., Sfar, I., Debbeche, R., Trabelsi, S., Gorgi, Y., Najjar, T., Chronic viral C hepatitis associated with primary biliary cirrhosis. Report of two cases (2009) Rev Med Interne, 30, pp. 537-539; Ramos-Casals, M., Pares, A., Jara, L.J., Solans, R., Vi{\~n}as, O., V{\'a}zquez, P., S{\'a}nchez-Tapias, Antimitochondrial antibodies in patients with chronic hepatitis C virus infection: Description of 18 cases and review of the literature (2005) J Viral Hepat, 12, pp. 648-654. , HISPAMEC Study Group; Sung, J.L., Prevention of hepatitis B and C virus infection for prevention of cirrhosis and hepatocellular carcinoma (1997) J Gastroenterol Hepatol, 12, pp. S370-S376; Wang, J.T., Wang, T.H., Sheu, J.C., Tsai, S.J., Hsieh, Y.S., Lin, D.T., Wang, C.Y., Hepatitis C virus infection in volunteer blood donors in Taiwan. Evaluation by hepatitis C antibody assays and the polymerase chain reaction (1993) Arch Pathol Lab Med, 117, pp. 152-156; Nakamura, M., Yasunami, M., Kondo, H., Horie, H., Aiba, Y., Komori, A., Migita, K., Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): The HLA-DRB1 polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC (2010) Hepatol Res, 40, pp. 494-504. , PBC Study Group in NHOSLJ; Gershwin, M.E., Selmi, C., Worman, H.J., Gold, E.B., Watnik, M., Utts, J., Lindor, K.D., Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview based study of 1032 patients (2005) Hepatology, 42, pp. 1194-1202; Ala, A., Stanca, C.M., Bu-Ghanim, M., Ahmado, I., Branch, A.D., Schiano, T.D., Odin, J.A., Increased prevalence of primary biliary cirrhosis near superfund toxic waste sites (2006) Hepatology, 43, pp. 525-531; Ishibashi, H., Komori, A., Shimoda, S., Ambrosini, Y.M., Gershwin, M.E., Nakamura, M., Risk factors and prediction of long-term outcome in primary biliary cirrhosis (2011) Intern Med, 50, pp. 1-10; Cavazza, A., Caballer{\'i}a, L., Floreani, A., Farinati, F., Bruguera, M., Caroli, D., Par{\'e}s, A., Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis: Comparative Analysis from Two Centers (2009) Hepatology, 50, pp. 1162-1168; Macaron, C., Hanouneh, I.A., Zein, N.N., Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis (2010) Hepatology, 52, p. 2239. , author reply 2239-40; Michel, F., Toussirot, E., Wendling, D., Primary biliary cirrhosis and systemic lupus erythematosus. A new case report (1998) Rev Rhum Engl Ed, 65, pp. 504-507; Shizuma, T., Kuroda, H., A case of primary biliary cirrhosis which developed eight years after diagnosis of systemic lupus erythematosus (2011) Intern Med, 50, pp. 321-324; Watt, E.F., James, O.F., Jones, D.E., Patterns of autoimmunity in primary biliary cirrhosis patients and their families: A population-based cohort study (2004) QJM, 97, pp. 397-406; Fried, M.W., Shiffman, M.L., Reddy, K.R., Smith, C., Marinos, G., Gon{\cc}ales Jr., F.L., H{\"a}ussinger, D., Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection (2002) N Engl J Med, 26, pp. 975-982; Yoshikawa, M., Mimura, M., Shiroi, A., Kojima, H., Fukui, H., Sugimoto, Y., Mochi, T., Primary biliary cirrhosis exacerbated by a course of acute hepatitis C and subsequent interferon therapy (2000) Am J Gastroenterol, 95, pp. 2396-2397; Maeda, T., Onishi, S., Miura, T., Iwamura, S., Tomita, A., Saibara, T., Yamamoto, Y., Exacerbation of primary biliary cirrhosis during interferon-alpha 2b therapy for chronic active hepatitis C (1995) Dig Dis Sci, 40, pp. 1226-1230; D'Amico, E., Paroli, M., Fratelli, V., Palazzi, C., Barnaba, V., Callea, F., Consoli, G., Primary biliary cirrhosis induced by interferon-alpha therapy for hepatitis C virus infection (1995) Dig Dis Sci, 40, pp. 2113-2116; Lok, A.S., Gardiner, D.F., Lawitz, E., Martorell, C., Everson, G.T., Ghalib, R., Reindollar, R., Preliminary study of two antiviral agents for hepatitis C genotype 1 (2012) N Engl J Med, 366, pp. 216-224; Chung, R.T., A Watershed Moment in the Treatment of Hepatitis C (2012) N Engl J Med, 366, pp. 273-275",
year = "2013",
language = "English",
volume = "12",
pages = "78--84",
journal = "Annals of Hepatology",
issn = "1665-2681",
publisher = "Mexican Association of Hepatology",
number = "1",

}

TY - JOUR

T1 - Hepatitis C virus infection in patients with primary biliary cirrhosis

AU - Chen, Hsuan-Wei

AU - Huang, Hsin-Hung

AU - Lai, Ching-Huang

AU - Chang, Wei-En

AU - Shih, Yu-Lueng

AU - Chang, Wei-Kuo

AU - Hsieh, Tsai-Yuan

AU - Chu, Heng-Cheng

N1 - 被引用次數:1 Export Date: 22 March 2016 通訊地址: Chu, H.-C.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan; 電子郵件: chu5583@ms55.hinet.net 化學物質/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; aspartate aminotransferase, 9000-97-9; bilirubin, 18422-02-1, 635-65-4; creatinine, 19230-81-0, 60-27-5; ribavirin, 36791-04-5 出資詳情: NSC94-2314-B-016-047, National Science Council Taiwan 參考文獻: Kaplan, M.M., Gershwin, M.E., Primary biliary cirrhosis (2006) N Engl J Med, 353, pp. 1261-1273; Myers, R.P., Shaheen, A.A., Fong, A., Burak, K.W., Wan, A., Swain, M.G., Hilsden, R.J., Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: A population-based study (2009) Hepatology, 50, p. 1884; Kumagi, T., Heathcote, E.J., Primary biliary cirrhosis (2008) Orphanet J Rare Dis, 3, p. 1; Poupon, R.E., Lindor, K.D., Parés, A., Chazouilleres, O., Poupon, R., Heathcote, E.J., Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis (2003) J Hepatol, 39, pp. 12-16; Davis, G.L., Albright, J.E., Cook, S.F., Rosenberg, D.M., Projecting future complications of chronic hepatitis C in the United-States (2003) Liver Transpl, 9, pp. 331-338; Haddad, J., Deny, P., Munz-Gotheil, C., Ambrosini, J.C., Trinchet, J.C., Pateron, D., Mal, F., Lymphocytic sialadenitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease (1992) Lancet, 339, pp. 321-323; Marcellin, P., Pouteau, M., Benhamou, J.P., Hepatitis C virus infection, alpha interferon therapy and thyroid dysfunction (1995) J Hepatol, 22, pp. 364-369; Lunel, F., Cacoub, P., Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection (1999) J Hepatol, 31, pp. 210-216; Floreani, A., Baragiotta, A., Leone, M.G., Baldo, V., Naccarato, R., Primary biliary cirrhosis and hepatitis C virus infection (2003) Am J Gastroenterol, 98, pp. 2757-2762; Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., Model for end-stage liver disease (MELD) and allocation of donor livers (2003) Gastroenterology, 124, pp. 91-96; Housset, C., Hirschauer, C., Degos, F., False positive anti-HCV in biliary cirrhosis (1991) Lancet, 114, p. 252. , (Letter); Fusconi, M., Lenzi, M., Ballardini, G., Miniero, R., Cassani, F., Zauli, D., Bianchi, F.B., Anti-HCV testing in autoimmune hepatitis and primary biliary cirrhosis (1990) Lancet, 336, p. 823; Imada, J., Hoshino, H., Nishimura, D., Morita, K., Yoshida, N., Katada, N., Sano, H., Case report: Multiple cancers: Hepatocellular carcinoma and adenocarcinomas of the common bile duct and the gall-bladder in a woman with primary biliary cirrhosis (1996) J Gastroenterol Hepatol, 11, pp. 546-550; Hoso, M., Nakanuma, Y., Kawano, M., Oda, K., Tsuneyama, K., van de water, J., Gershiwin, M.E., Granulomatous cholangitis in chronic hepatitis C: A new diagnostic problem in liver pathology (1996) Pathol Int, 46, pp. 301-305; Mouelhi, L., Chaieb, M., Sfar, I., Debbeche, R., Trabelsi, S., Gorgi, Y., Najjar, T., Chronic viral C hepatitis associated with primary biliary cirrhosis. Report of two cases (2009) Rev Med Interne, 30, pp. 537-539; Ramos-Casals, M., Pares, A., Jara, L.J., Solans, R., Viñas, O., Vázquez, P., Sánchez-Tapias, Antimitochondrial antibodies in patients with chronic hepatitis C virus infection: Description of 18 cases and review of the literature (2005) J Viral Hepat, 12, pp. 648-654. , HISPAMEC Study Group; Sung, J.L., Prevention of hepatitis B and C virus infection for prevention of cirrhosis and hepatocellular carcinoma (1997) J Gastroenterol Hepatol, 12, pp. S370-S376; Wang, J.T., Wang, T.H., Sheu, J.C., Tsai, S.J., Hsieh, Y.S., Lin, D.T., Wang, C.Y., Hepatitis C virus infection in volunteer blood donors in Taiwan. Evaluation by hepatitis C antibody assays and the polymerase chain reaction (1993) Arch Pathol Lab Med, 117, pp. 152-156; Nakamura, M., Yasunami, M., Kondo, H., Horie, H., Aiba, Y., Komori, A., Migita, K., Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): The HLA-DRB1 polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC (2010) Hepatol Res, 40, pp. 494-504. , PBC Study Group in NHOSLJ; Gershwin, M.E., Selmi, C., Worman, H.J., Gold, E.B., Watnik, M., Utts, J., Lindor, K.D., Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview based study of 1032 patients (2005) Hepatology, 42, pp. 1194-1202; Ala, A., Stanca, C.M., Bu-Ghanim, M., Ahmado, I., Branch, A.D., Schiano, T.D., Odin, J.A., Increased prevalence of primary biliary cirrhosis near superfund toxic waste sites (2006) Hepatology, 43, pp. 525-531; Ishibashi, H., Komori, A., Shimoda, S., Ambrosini, Y.M., Gershwin, M.E., Nakamura, M., Risk factors and prediction of long-term outcome in primary biliary cirrhosis (2011) Intern Med, 50, pp. 1-10; Cavazza, A., Caballería, L., Floreani, A., Farinati, F., Bruguera, M., Caroli, D., Parés, A., Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis: Comparative Analysis from Two Centers (2009) Hepatology, 50, pp. 1162-1168; Macaron, C., Hanouneh, I.A., Zein, N.N., Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis (2010) Hepatology, 52, p. 2239. , author reply 2239-40; Michel, F., Toussirot, E., Wendling, D., Primary biliary cirrhosis and systemic lupus erythematosus. A new case report (1998) Rev Rhum Engl Ed, 65, pp. 504-507; Shizuma, T., Kuroda, H., A case of primary biliary cirrhosis which developed eight years after diagnosis of systemic lupus erythematosus (2011) Intern Med, 50, pp. 321-324; Watt, E.F., James, O.F., Jones, D.E., Patterns of autoimmunity in primary biliary cirrhosis patients and their families: A population-based cohort study (2004) QJM, 97, pp. 397-406; Fried, M.W., Shiffman, M.L., Reddy, K.R., Smith, C., Marinos, G., Gonçales Jr., F.L., Häussinger, D., Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection (2002) N Engl J Med, 26, pp. 975-982; Yoshikawa, M., Mimura, M., Shiroi, A., Kojima, H., Fukui, H., Sugimoto, Y., Mochi, T., Primary biliary cirrhosis exacerbated by a course of acute hepatitis C and subsequent interferon therapy (2000) Am J Gastroenterol, 95, pp. 2396-2397; Maeda, T., Onishi, S., Miura, T., Iwamura, S., Tomita, A., Saibara, T., Yamamoto, Y., Exacerbation of primary biliary cirrhosis during interferon-alpha 2b therapy for chronic active hepatitis C (1995) Dig Dis Sci, 40, pp. 1226-1230; D'Amico, E., Paroli, M., Fratelli, V., Palazzi, C., Barnaba, V., Callea, F., Consoli, G., Primary biliary cirrhosis induced by interferon-alpha therapy for hepatitis C virus infection (1995) Dig Dis Sci, 40, pp. 2113-2116; Lok, A.S., Gardiner, D.F., Lawitz, E., Martorell, C., Everson, G.T., Ghalib, R., Reindollar, R., Preliminary study of two antiviral agents for hepatitis C genotype 1 (2012) N Engl J Med, 366, pp. 216-224; Chung, R.T., A Watershed Moment in the Treatment of Hepatitis C (2012) N Engl J Med, 366, pp. 273-275

PY - 2013

Y1 - 2013

N2 - Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.

AB - Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.

KW - Child-Pugh score

KW - Cirrhosis

KW - MELD score

KW - alanine aminotransferase

KW - albumin

KW - aspartate aminotransferase

KW - bilirubin

KW - creatinine

KW - interferon

KW - ribavirin

KW - virus RNA

KW - adult

KW - age

KW - aged

KW - article

KW - ascites

KW - autoimmune disease

KW - bleeding

KW - Child Pugh score

KW - clinical article

KW - comorbidity

KW - controlled study

KW - death

KW - disease severity

KW - female

KW - follow up

KW - hepatitis C

KW - human

KW - international normalized ratio

KW - liver cell carcinoma

KW - liver cirrhosis

KW - male

KW - medical record review

KW - Model For End Stage Liver Disease Score

KW - neoplasm

KW - primary biliary cirrhosis

KW - survival rate

KW - virus load

KW - biliary cirrhosis

KW - case control study

KW - disease course

KW - middle aged

KW - prognosis

KW - retrospective study

KW - severity of illness index

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Disease Progression

KW - Female

KW - Hepatitis C

KW - Humans

KW - Liver Cirrhosis, Biliary

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Retrospective Studies

KW - Severity of Illness Index

M3 - Article

VL - 12

SP - 78

EP - 84

JO - Annals of Hepatology

JF - Annals of Hepatology

SN - 1665-2681

IS - 1

ER -