Hepatitis B virus marker in Chinese twins

T. M. Lin, C. J. Chen, M. M. Wu, C. S. Yang, J. S. Chen, C. C. Lin, T. Y. Kwang, S. T. Hsu, S. Y. Lin, L. C. Hsu

Research output: Contribution to journalArticle

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Abstract

Chinese same-sex twins were recruited in order to study the distribution of different markers of hepatitis B virus (HBV) infection, including HBV surface antigen (HBsAg), antibody to HBV core antigen (anti-HBc), antibody to HBsAg (anti-HBs), HBV e antigen (HBeAg) and antibody to HBeAg (Anti-HBe), as well as to compare the concordance of these markers in pair-wise fashion among monozygotic (MZ) and dizygotic (DZ) twins and singleton controls. A total of 289 pairs of MZ twins, 102 pairs of DZ twins and 375 pairs of age-sex-matched singleton controls were studied. More than 50 percent of the members of each group (64.71% of MZ twins, 51.96% of DZ twins and 62.13% of controls) were found to be infected with HBV. In general, the patterns of the response to HBV infection in the 3 groups were similarly distributed. 20.17% of the members of the 3 groups (21.45% of MZ twins, 14.22% of DZ twins, and 20.80% of controls) were HBsAg carriers. Among the HBsAg carriers, 49.19% (44.35% of MZ twins, 34.48% of DZ twins and 55.77% of controls) were HBeAg carriers. No significant difference in the concordance of HBV infection was observed in the MZ and DZ twins. However, highly significant differences were noted between MZ twins and controls, and between DZ twins and controls. Highly significant differences were also observed in the concordance of carrier status between MZ an DZ twins and between MZ twins and controls, but not between DZ and controls. As for the other HBV markers, no significant differences were observed. It is concluded that the genetic influence in response to HBV infection markers is not well-characterized and requires further study.

Original languageEnglish
Pages (from-to)737-741
Number of pages5
JournalAnticancer Research
Volume9
Issue number3
Publication statusPublished - Jan 1 1989
Externally publishedYes

Fingerprint

Monozygotic Twins
Dizygotic Twins
Hepatitis B virus
Virus Diseases
Hepatitis B e Antigens
Surface Antigens
Hepatitis B Core Antigens
Hepatitis B Antibodies
Antibodies
Hepatitis B Surface Antigens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lin, T. M., Chen, C. J., Wu, M. M., Yang, C. S., Chen, J. S., Lin, C. C., ... Hsu, L. C. (1989). Hepatitis B virus marker in Chinese twins. Anticancer Research, 9(3), 737-741.

Hepatitis B virus marker in Chinese twins. / Lin, T. M.; Chen, C. J.; Wu, M. M.; Yang, C. S.; Chen, J. S.; Lin, C. C.; Kwang, T. Y.; Hsu, S. T.; Lin, S. Y.; Hsu, L. C.

In: Anticancer Research, Vol. 9, No. 3, 01.01.1989, p. 737-741.

Research output: Contribution to journalArticle

Lin, TM, Chen, CJ, Wu, MM, Yang, CS, Chen, JS, Lin, CC, Kwang, TY, Hsu, ST, Lin, SY & Hsu, LC 1989, 'Hepatitis B virus marker in Chinese twins', Anticancer Research, vol. 9, no. 3, pp. 737-741.
Lin TM, Chen CJ, Wu MM, Yang CS, Chen JS, Lin CC et al. Hepatitis B virus marker in Chinese twins. Anticancer Research. 1989 Jan 1;9(3):737-741.
Lin, T. M. ; Chen, C. J. ; Wu, M. M. ; Yang, C. S. ; Chen, J. S. ; Lin, C. C. ; Kwang, T. Y. ; Hsu, S. T. ; Lin, S. Y. ; Hsu, L. C. / Hepatitis B virus marker in Chinese twins. In: Anticancer Research. 1989 ; Vol. 9, No. 3. pp. 737-741.
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title = "Hepatitis B virus marker in Chinese twins",
abstract = "Chinese same-sex twins were recruited in order to study the distribution of different markers of hepatitis B virus (HBV) infection, including HBV surface antigen (HBsAg), antibody to HBV core antigen (anti-HBc), antibody to HBsAg (anti-HBs), HBV e antigen (HBeAg) and antibody to HBeAg (Anti-HBe), as well as to compare the concordance of these markers in pair-wise fashion among monozygotic (MZ) and dizygotic (DZ) twins and singleton controls. A total of 289 pairs of MZ twins, 102 pairs of DZ twins and 375 pairs of age-sex-matched singleton controls were studied. More than 50 percent of the members of each group (64.71{\%} of MZ twins, 51.96{\%} of DZ twins and 62.13{\%} of controls) were found to be infected with HBV. In general, the patterns of the response to HBV infection in the 3 groups were similarly distributed. 20.17{\%} of the members of the 3 groups (21.45{\%} of MZ twins, 14.22{\%} of DZ twins, and 20.80{\%} of controls) were HBsAg carriers. Among the HBsAg carriers, 49.19{\%} (44.35{\%} of MZ twins, 34.48{\%} of DZ twins and 55.77{\%} of controls) were HBeAg carriers. No significant difference in the concordance of HBV infection was observed in the MZ and DZ twins. However, highly significant differences were noted between MZ twins and controls, and between DZ twins and controls. Highly significant differences were also observed in the concordance of carrier status between MZ an DZ twins and between MZ twins and controls, but not between DZ and controls. As for the other HBV markers, no significant differences were observed. It is concluded that the genetic influence in response to HBV infection markers is not well-characterized and requires further study.",
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