Hepatitis B virus infection and the risk of male infertility: A population-based analysis

Fu-Hsiung Su, Shih Ni Chang, Fung Chang Sung, Chien-Tien Su, Ying-Hua Shieh, Cheng Chieh Lin, Chih-Ching Yeh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

Original languageEnglish
Pages (from-to)1677-1684
Number of pages8
JournalFertility and Sterility
Volume102
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Male Infertility
Virus Diseases
Hepatitis B virus
Population
Infertility
Incidence
International Classification of Diseases
Proportional Hazards Models
Cohort Studies
Outcome Assessment (Health Care)
Confidence Intervals

Keywords

  • Hepatitis B virus
  • Male infertility
  • Population-based study

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Hepatitis B virus infection and the risk of male infertility : A population-based analysis. / Su, Fu-Hsiung; Chang, Shih Ni; Sung, Fung Chang; Su, Chien-Tien; Shieh, Ying-Hua; Lin, Cheng Chieh; Yeh, Chih-Ching.

In: Fertility and Sterility, Vol. 102, No. 6, 01.12.2014, p. 1677-1684.

Research output: Contribution to journalArticle

Su, Fu-Hsiung ; Chang, Shih Ni ; Sung, Fung Chang ; Su, Chien-Tien ; Shieh, Ying-Hua ; Lin, Cheng Chieh ; Yeh, Chih-Ching. / Hepatitis B virus infection and the risk of male infertility : A population-based analysis. In: Fertility and Sterility. 2014 ; Vol. 102, No. 6. pp. 1677-1684.
@article{3c97e497924646cf923424f4ef84734b,
title = "Hepatitis B virus infection and the risk of male infertility: A population-based analysis",
abstract = "Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95{\%} confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.",
keywords = "Hepatitis B virus, Male infertility, Population-based study",
author = "Fu-Hsiung Su and Chang, {Shih Ni} and Sung, {Fung Chang} and Chien-Tien Su and Ying-Hua Shieh and Lin, {Cheng Chieh} and Chih-Ching Yeh",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.fertnstert.2014.09.017",
language = "English",
volume = "102",
pages = "1677--1684",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Hepatitis B virus infection and the risk of male infertility

T2 - A population-based analysis

AU - Su, Fu-Hsiung

AU - Chang, Shih Ni

AU - Sung, Fung Chang

AU - Su, Chien-Tien

AU - Shieh, Ying-Hua

AU - Lin, Cheng Chieh

AU - Yeh, Chih-Ching

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

AB - Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

KW - Hepatitis B virus

KW - Male infertility

KW - Population-based study

UR - http://www.scopus.com/inward/record.url?scp=84922014631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922014631&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2014.09.017

DO - 10.1016/j.fertnstert.2014.09.017

M3 - Article

C2 - 25439807

AN - SCOPUS:84922014631

VL - 102

SP - 1677

EP - 1684

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -