Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b virus infection in Taiwan

Fang Yeh Chu, Fu Hsiung Su, Shu Hsing Cheng, Yu Shiang Lin, Chung Yi Li, Chih Ching Chien, Yu Cheng Lin, Shuo Ya Chiang

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4 Citations (Scopus)

Abstract

This study aimed to examine the application of hepatitis B surface antigen (HBsAg) confirmatory testing when diagnosing hepatitis B infection among young persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg status, the presence of antibodies against HBsAg (anti-HBs), and the presence of antibodies against hepatitis B core antigen (anti-HBc) were compared among 403 graduate students (mean age 22.8±0.7 years) and 1,745 undergraduate students (18.6±1.0 years) from one university, and 367 adult subjects (41.1±15.8 years) in 2008. Any HBsAg-positive subjects were tested with an HBsAg confirmatory test. Chi-square tests for trend and predictive values of positivity (PVP) when using HBsAg-positive only for determining confirmed cases of hepatitis B infection were compared across the three cohorts. The prevalence of HBsAg positivity among subjects decreased from 16.3% in the adults to 5.2% in the graduate students and then to 2.8% for the undergraduate students (P=0.0007). The PVP of HBsAg testing when determining cases of hepatitis B decreased from 0.97 for the adults to 0.81 for the graduate students and then to 0.56 for the undergraduate students (P

Original languageEnglish
Pages (from-to)1514-1521
Number of pages8
JournalJournal of Medical Virology
Volume83
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Keywords

  • Hepatitis B surface antigen
  • Neutralization test
  • Taiwan

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Chu, F. Y., Su, F. H., Cheng, S. H., Lin, Y. S., Li, C. Y., Chien, C. C., Lin, Y. C., & Chiang, S. Y. (2011). Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis b virus infection in Taiwan. Journal of Medical Virology, 83(9), 1514-1521. https://doi.org/10.1002/jmv.22127