Hepatitis B seroprevalence and anamnestic response amongst Taiwanese young adults with full vaccination in infancy, 20 years subsequent to national hepatitis B vaccination

Fu Hsiung Su, Shu Hsing Cheng, Chung Yi Li, Jong Dar Chen, Chih Yin Hsiao, Chih Ching Chien, Ya Chuan Yang, Hsiu Hsing Hung, Fang Yeh Chu

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The long-term protective effect of hepatitis B virus (HB) vaccination against HB infection and the necessity for routine booster vaccination in young-adult age subsequent to full HB immunization at birth remain issues of some debate currently. This study is aimed at evaluating the seroprevalence of HB infection and the response to HB booster vaccination amongst young-adult university students who had previously undergone full vaccination during their infancy. Eight hundred and forty-three subjects (mean age 18.7 ± 0.4 years), 492 males and 351 females, with a complete HB vaccination during infancy were enrolled into this study. The prevalence of natural HB infection, chronic HB-carrier status, and HB-naïve group was, respectively, 4.1%, 1.4%, and 62.3%. Amongst 316 study subjects who were naïve to HB infection and had received one HB booster at time of university entrance health examination, 49.6%, 91.4%, and 97.5% of the participants with a serum anti-HBs level

Original languageEnglish
Pages (from-to)8085-8090
Number of pages6
JournalVaccine
Volume25
Issue number47
DOIs
Publication statusPublished - Nov 19 2007
Externally publishedYes

Keywords

  • Booster dose
  • Hepatitis B antibodies
  • Hepatitis B vaccination
  • Taiwan

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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