Hepatic failure related to itraconazole use successfully treated by corticosteroids

Horng Yuan Lou, Chia Lang Fang, Sheng Uei Fang, Cheng Tiong, Yang Chih Cheng, Chun Chao Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Itraconazole is believed to carry a low risk of hepatic toxicity owing to its low affinity for the human P-450 enzyme. Therefore, hepatic failure caused by itraconazole is exceedingly rare. Objectives: We report the case of a 46-year-old woman who developed hepatic failure related to itraconazole that was administered for the treatment of onychomycosis. Her condition deteriorated after withdrawal of the drug, followed solely by supportive care initially. Case Report: Treatment with corticosteroids was started 10 days after her admission, and her condition gradually improved. Unfortunately, her condition worsened when the dosage of corticosteroids was abruptly decreased. Ultimately, her condition improved with appropriate adjustments of corticosteroid dosage. Discussion: We conclude that corticosteroid therapy may be effective for itraconazole-induced hepatitis, especially in those patients who do not respond to conservative treatment. Notably, any decrease in the dosage should be performed with caution. We also recommend that close monitoring of liver function is mandatory during the use of itraconazole.

Original languageEnglish
Pages (from-to)843-846
Number of pages4
JournalHepatitis Monthly
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Adrenal Cortex Hormones
  • Itraconazole
  • Liver Failure

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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