Hemolysis in double-filtration plasmapheresis

Jiann Horng Yeh, Wei Hung Chen, Hou Chang Chiu, Chyi Huey Bai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Fingerprint

Plasmapheresis
Hemolysis
Pressure
Vascular Access Devices
Venous Pressure
Muscle Weakness
Blood Vessels
Veins
Arterial Pressure
Therapeutics

Keywords

  • Double-filtration plasmapheresis
  • Hemolysis
  • Heparin
  • Transmembrane pressure
  • Vascular access

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hemolysis in double-filtration plasmapheresis. / Yeh, Jiann Horng; Chen, Wei Hung; Chiu, Hou Chang; Bai, Chyi Huey.

In: American Journal of Clinical Pathology, Vol. 127, No. 1, 01.2007, p. 76-80.

Research output: Contribution to journalArticle

Yeh, Jiann Horng ; Chen, Wei Hung ; Chiu, Hou Chang ; Bai, Chyi Huey. / Hemolysis in double-filtration plasmapheresis. In: American Journal of Clinical Pathology. 2007 ; Vol. 127, No. 1. pp. 76-80.
@article{564596125ab345dabe282ce6a6191bf1,
title = "Hemolysis in double-filtration plasmapheresis",
abstract = "To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4{\%}. Peripheral venous access was associated with a higher rate of hemolysis (45.3{\%}). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.",
keywords = "Double-filtration plasmapheresis, Hemolysis, Heparin, Transmembrane pressure, Vascular access",
author = "Yeh, {Jiann Horng} and Chen, {Wei Hung} and Chiu, {Hou Chang} and Bai, {Chyi Huey}",
year = "2007",
month = "1",
doi = "10.1309/F8XMTALTTCE5H37U",
language = "English",
volume = "127",
pages = "76--80",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

TY - JOUR

T1 - Hemolysis in double-filtration plasmapheresis

AU - Yeh, Jiann Horng

AU - Chen, Wei Hung

AU - Chiu, Hou Chang

AU - Bai, Chyi Huey

PY - 2007/1

Y1 - 2007/1

N2 - To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

AB - To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

KW - Double-filtration plasmapheresis

KW - Hemolysis

KW - Heparin

KW - Transmembrane pressure

KW - Vascular access

UR - http://www.scopus.com/inward/record.url?scp=34249026392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249026392&partnerID=8YFLogxK

U2 - 10.1309/F8XMTALTTCE5H37U

DO - 10.1309/F8XMTALTTCE5H37U

M3 - Article

VL - 127

SP - 76

EP - 80

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 1

ER -