Hemolysis in double-filtration plasmapheresis

Jiann Horng Yeh, Wei Hung Chen, Hou Chang Chiu, Chyi Huey Bai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Keywords

  • Double-filtration plasmapheresis
  • Hemolysis
  • Heparin
  • Transmembrane pressure
  • Vascular access

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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