Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis

Yu Hsueh Wu, Julia Yu-Fong Chang, Yi Ping Wang, Yang Che Wu, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG + RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Results: We found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG + RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1% of 33 AG־RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG + RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AG־RAS/BD patients. In addition, the 33 AG־RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). Conclusion: We conclude that AG + RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AG־RAS/BD patients.

Original languageEnglish
Pages (from-to)559-565
Number of pages7
JournalJournal of the Formosan Medical Association
Volume117
Issue number7
DOIs
Publication statusPublished - Jul 1 2018
Externally publishedYes

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Glossitis
Folic Acid Deficiency
Hyperhomocysteinemia
Behcet Syndrome
Vitamin B 12
Hemoglobins
Iron
Healthy Volunteers
Vitamin B 12 Deficiency
Sutton disease 2
Homocysteine
Folic Acid

Keywords

  • Atrophic glossitis
  • Behcet's disease
  • Hemoglobin
  • Hyperhomocysteinemia
  • Iron
  • Vitamin B12

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. / Wu, Yu Hsueh; Yu-Fong Chang, Julia; Wang, Yi Ping; Wu, Yang Che; Chen, Hsin Ming; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 117, No. 7, 01.07.2018, p. 559-565.

Research output: Contribution to journalArticle

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abstract = "Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG + RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Results: We found that 43.3{\%}, 33.3{\%}, 13.3{\%}, 6.7{\%}, and 20.0{\%} of 30 AG + RAS/BD patients and 18.2{\%}, 36.4{\%}, 0{\%}, 6.1{\%}, and 9.1{\%} of 33 AG־RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG + RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AG־RAS/BD patients. In addition, the 33 AG־RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). Conclusion: We conclude that AG + RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AG־RAS/BD patients.",
keywords = "Atrophic glossitis, Behcet's disease, Hemoglobin, Hyperhomocysteinemia, Iron, Vitamin B12",
author = "Wu, {Yu Hsueh} and {Yu-Fong Chang}, Julia and Wang, {Yi Ping} and Wu, {Yang Che} and Chen, {Hsin Ming} and Andy Sun",
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TY - JOUR

T1 - Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis

AU - Wu, Yu Hsueh

AU - Yu-Fong Chang, Julia

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Chen, Hsin Ming

AU - Sun, Andy

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG + RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Results: We found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG + RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1% of 33 AG־RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG + RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AG־RAS/BD patients. In addition, the 33 AG־RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). Conclusion: We conclude that AG + RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AG־RAS/BD patients.

AB - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG + RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Results: We found that 43.3%, 33.3%, 13.3%, 6.7%, and 20.0% of 30 AG + RAS/BD patients and 18.2%, 36.4%, 0%, 6.1%, and 9.1% of 33 AG־RAS/BD patients had hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia, respectively. Moreover, 30 AG + RAS/BD patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects (all P-values < 0.05), and had a higher frequency of hemoglobin deficiency (P = 0.058, marginal significance) and a significantly higher frequency of vitamin B12 deficiency (P = 0.046) than 33 AG־RAS/BD patients. In addition, the 33 AG־RAS/BD patients had significantly higher frequencies of hemoglobin and iron deficiencies than healthy control subjects (both P-values < 0.001). Conclusion: We conclude that AG + RAS/BD patients do have significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than healthy control subjects and have significantly higher frequencies of hemoglobin and vitamin B12 deficiencies than AG־RAS/BD patients.

KW - Atrophic glossitis

KW - Behcet's disease

KW - Hemoglobin

KW - Hyperhomocysteinemia

KW - Iron

KW - Vitamin B12

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DO - 10.1016/j.jfma.2018.03.005

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EP - 565

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

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