Hemodynamic response of modified fluid gelatin compared with lactated ringer's solution for volume expansion in emergency resuscitation of hypovolemic shock patients: Preliminary report of a prospective, randomized trial

Jackson Jer Kan Wu, Mu Shun Huang, Gau Jun Tang, Wei Fong Kao, Hsin Chin Shih, Cheng Hsi Su, Chen Hsen Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The objective of this study was to compare the cardiac and hemodynamic responses to a rapid infusion of 1000 ml of modified fluid gelatin (group A) or 1000 ml of lactated Ringer's solution (group B) in emergency room patients suffering from shock. This prospective, randomized, open, noncrossover study was performed at a medical center university hospital in a surgical resuscitation room in the emergency department. The subjects were 34 patients with either hypovolemic or neurogenic shock who were admitted to the emergency room. A resuscitation protocol according to Advanced Trauma Life Support (ATLS) with an additional central venous line or Swan-Ganz catheters for hemodynamic monitoring was used. Physical parameters and hemodynamic variables were measured at baseline and 15 minutes, 30 minutes, and 1 hour after the infusion of each fluid. In both groups the mean arterial blood pressure (MAP), systolic and diastolic pressure, central venous pressure (CVP), and pulmonary artery occlusion pressure (PAOP) increased significantly. The CVP and PAOP increased significantly more in the modified fluid gelatin resuscitation group. In patients with traumatic or neurogenic shock due to acute volume deficiency, there was significantly better hemodynamic improvement, judged by CVP and PAOP measurements using the modified fluid gelatin for volume replacement than with lactated Ringer's solution during the first hour of resuscitation.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalWorld Journal of Surgery
Volume25
Issue number5
DOIs
Publication statusPublished - May 2001
Externally publishedYes

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Resuscitation
Central Venous Pressure
Shock
Emergencies
Hemodynamics
Pulmonary Artery
Hospital Emergency Service
Pressure
Arterial Pressure
Advanced Trauma Life Support Care
Blood Pressure
Hypovolemia
Catheters
Ringer's solution
Ringer's lactate
modified fluid gelatins

ASJC Scopus subject areas

  • Surgery

Cite this

Hemodynamic response of modified fluid gelatin compared with lactated ringer's solution for volume expansion in emergency resuscitation of hypovolemic shock patients : Preliminary report of a prospective, randomized trial. / Wu, Jackson Jer Kan; Huang, Mu Shun; Tang, Gau Jun; Kao, Wei Fong; Shih, Hsin Chin; Su, Cheng Hsi; Lee, Chen Hsen.

In: World Journal of Surgery, Vol. 25, No. 5, 05.2001, p. 598-602.

Research output: Contribution to journalArticle

Wu, Jackson Jer Kan ; Huang, Mu Shun ; Tang, Gau Jun ; Kao, Wei Fong ; Shih, Hsin Chin ; Su, Cheng Hsi ; Lee, Chen Hsen. / Hemodynamic response of modified fluid gelatin compared with lactated ringer's solution for volume expansion in emergency resuscitation of hypovolemic shock patients : Preliminary report of a prospective, randomized trial. In: World Journal of Surgery. 2001 ; Vol. 25, No. 5. pp. 598-602.
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