Hemodialysis reduces the viral load in uremic patients with chronic hepatitis B infection

Guan Ying Tseng, Hwai Jeng Lin, Chen Tsong Fang, Yu Tang Cheng, Ching Hui Huang, Guan Chin Tseng, Po Chien Wang, Tsai Li Hung, Yao Chou Deng, Chung Chi Tsai, Kuang Yao Yang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and aims. The effect of hemodialysis (HD) to change the viral load of hepatitis B virus (HBV) in uremic patients with chronic HBV infection has never been studied. In this study, we investigated the HBV viral loads and their changes between the HD procedure in the uremic patients. Patients and methods. A total of 38 chronic HBV-infected uremic patients were enrolled, but eight cases were excluded due to HCV co-infection and under anti-viral therapy. To evaluate the HBV DNA levels and their changes through the course of HD, we quantified serial serum samples from each patient immediately before HD, at the end of HD, and 48 hours later - immediately before the next HD. Results. Most of our HBV-infected uremic patients had a relatively lower HBV viral load; 80% cases with HBV DNA ≦4 Log10copies/mL, in comparison with the Taiwan epidemiologic study for community base HBV carriers. There was no significant difference of HBV DNA level between HBeAg-positive and -negative patients, but a significant higher DNA level in the high ALT group (p = 0.029) and liver cirrhosis patients (p = 0.002). The mean HBV DNA levels, before and after HD, respectively, in our 30 patients were 3.823 ± 1.130 Log10copies/mL and 3.686 ± 1.114 Log10copies/mL. It was a significant decrease on HBV DNA level in chronic HBV-infected patients through HD procedure (p = 0.004). The mean HBV DNA level of two days after HD was 3.702 ± 1.094 Log10copies/mL, which was not significantly different from the HBV DNA level before (p = 0.076) or after (p = 0.267) HD; however, the mean reduction of HBV DNA by a single HD was 0.11 ± 0.38 Log10copies/mL. Patients with low viral load also had a significant high platelet count (p = 0.03), high serum albumin (p = 0.016), and low AST level (p = 0.002). Conclusions. Most uremic patients with chronic HBV infection under regular HD in Taiwan had a relatively lower viral load, of which the major mechanism could be due to the elimination of serum HBV viral load by the HD procedure.

Original languageEnglish
Pages (from-to)1000-1005
Number of pages6
JournalRenal Failure
Volume30
Issue number10
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Chronic Hepatitis B
Viral Load
Hepatitis B virus
Renal Dialysis
Infection
DNA
Virus Diseases
Taiwan
Hepatitis B e Antigens
Serum
Coinfection
Platelet Count

Keywords

  • HBV DNA
  • Hemodialysis
  • Hepatitis B
  • Uremia
  • Viral load

ASJC Scopus subject areas

  • Nephrology
  • Critical Care and Intensive Care Medicine

Cite this

Tseng, G. Y., Lin, H. J., Fang, C. T., Cheng, Y. T., Huang, C. H., Tseng, G. C., ... Yang, K. Y. (2008). Hemodialysis reduces the viral load in uremic patients with chronic hepatitis B infection. Renal Failure, 30(10), 1000-1005. https://doi.org/10.1080/08860220802406377

Hemodialysis reduces the viral load in uremic patients with chronic hepatitis B infection. / Tseng, Guan Ying; Lin, Hwai Jeng; Fang, Chen Tsong; Cheng, Yu Tang; Huang, Ching Hui; Tseng, Guan Chin; Wang, Po Chien; Hung, Tsai Li; Deng, Yao Chou; Tsai, Chung Chi; Yang, Kuang Yao.

In: Renal Failure, Vol. 30, No. 10, 11.2008, p. 1000-1005.

Research output: Contribution to journalArticle

Tseng, GY, Lin, HJ, Fang, CT, Cheng, YT, Huang, CH, Tseng, GC, Wang, PC, Hung, TL, Deng, YC, Tsai, CC & Yang, KY 2008, 'Hemodialysis reduces the viral load in uremic patients with chronic hepatitis B infection', Renal Failure, vol. 30, no. 10, pp. 1000-1005. https://doi.org/10.1080/08860220802406377
Tseng, Guan Ying ; Lin, Hwai Jeng ; Fang, Chen Tsong ; Cheng, Yu Tang ; Huang, Ching Hui ; Tseng, Guan Chin ; Wang, Po Chien ; Hung, Tsai Li ; Deng, Yao Chou ; Tsai, Chung Chi ; Yang, Kuang Yao. / Hemodialysis reduces the viral load in uremic patients with chronic hepatitis B infection. In: Renal Failure. 2008 ; Vol. 30, No. 10. pp. 1000-1005.
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AU - Huang, Ching Hui

AU - Tseng, Guan Chin

AU - Wang, Po Chien

AU - Hung, Tsai Li

AU - Deng, Yao Chou

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AU - Yang, Kuang Yao

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N2 - Background and aims. The effect of hemodialysis (HD) to change the viral load of hepatitis B virus (HBV) in uremic patients with chronic HBV infection has never been studied. In this study, we investigated the HBV viral loads and their changes between the HD procedure in the uremic patients. Patients and methods. A total of 38 chronic HBV-infected uremic patients were enrolled, but eight cases were excluded due to HCV co-infection and under anti-viral therapy. To evaluate the HBV DNA levels and their changes through the course of HD, we quantified serial serum samples from each patient immediately before HD, at the end of HD, and 48 hours later - immediately before the next HD. Results. Most of our HBV-infected uremic patients had a relatively lower HBV viral load; 80% cases with HBV DNA ≦4 Log10copies/mL, in comparison with the Taiwan epidemiologic study for community base HBV carriers. There was no significant difference of HBV DNA level between HBeAg-positive and -negative patients, but a significant higher DNA level in the high ALT group (p = 0.029) and liver cirrhosis patients (p = 0.002). The mean HBV DNA levels, before and after HD, respectively, in our 30 patients were 3.823 ± 1.130 Log10copies/mL and 3.686 ± 1.114 Log10copies/mL. It was a significant decrease on HBV DNA level in chronic HBV-infected patients through HD procedure (p = 0.004). The mean HBV DNA level of two days after HD was 3.702 ± 1.094 Log10copies/mL, which was not significantly different from the HBV DNA level before (p = 0.076) or after (p = 0.267) HD; however, the mean reduction of HBV DNA by a single HD was 0.11 ± 0.38 Log10copies/mL. Patients with low viral load also had a significant high platelet count (p = 0.03), high serum albumin (p = 0.016), and low AST level (p = 0.002). Conclusions. Most uremic patients with chronic HBV infection under regular HD in Taiwan had a relatively lower viral load, of which the major mechanism could be due to the elimination of serum HBV viral load by the HD procedure.

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KW - Hemodialysis

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