Hemocompatibility of diamondlike carbon-metal composite thin films

Melanie Andara, Arvind Agarwal, Dirk Scholvin, Rosario A. Gerhardt, Anand Doraiswamy, Chunming Jin, Roger J. Narayan, Chun C. Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su

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Abstract

We have investigated the hemocompatibility of diamondlike carbon-silver composite and diamondlike carbon-titanium composite thin films prepared using a multicomponent target pulsed laser deposition process. These materials were examined using transmission electron microscopy, Raman spectroscopy, nanoindentation, electrochemical charge transfer testing, and platelet adhesion testing. Cross-sectional transmission electron microscopy revealed that silver self-assembles into nanoparticle arrays within the diamondlike carbon matrix in the diamondlike carbon-silver composite film. On the other hand, titanium self-assembles into alternating nanometer-thick titanium carbide layers within the diamondlike carbon matrix in the diamondlike carbon-titanium composite film. The hemocompatibility of these materials was examined using electrochemical charge transfer testing and platelet adhesion testing. A few small, widely scattered crystals were observed on the surface of the unalloyed diamondlike carbon film exposed to platelet rich plasma. On the other hand, dense fibrin networks with densely aggregated platelets were observed on the surfaces of diamondlike carbon-silver and diamondlike carbon-titanium composite thin films exposed to platelet rich plasma. Electrochemical testing revealed that the time constant for the diamondlike carbon thin film (λ = 1) was significantly higher than those for the diamondlike carbon-silver and diamondlike carbon-titanium composite thin films. These results suggest possible uses for diamondlike carbon thin films and diamondlike carbon-metal composite thin films as coatings in next generation cardiovascular implants.

Original languageEnglish
Pages (from-to)1941-1948
Number of pages8
JournalDiamond and Related Materials
Volume15
Issue number11-12 SPEC. ISS.
DOIs
Publication statusPublished - Nov 2006

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Keywords

  • Diamondlike carbon
  • Hemocompatibility
  • Pulsed laser deposition

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Andara, M., Agarwal, A., Scholvin, D., Gerhardt, R. A., Doraiswamy, A., Jin, C., Narayan, R. J., Shih, C. C., Shih, C. M., Lin, S. J., & Su, Y. Y. (2006). Hemocompatibility of diamondlike carbon-metal composite thin films. Diamond and Related Materials, 15(11-12 SPEC. ISS.), 1941-1948. https://doi.org/10.1016/j.diamond.2006.05.013