Hemocompatibility of diamondlike carbon-metal composite thin films

Melanie Andara, Arvind Agarwal, Dirk Scholvin, Rosario A. Gerhardt, Anand Doraiswamy, Chunming Jin, Roger J. Narayan, Chun C. Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We have investigated the hemocompatibility of diamondlike carbon-silver composite and diamondlike carbon-titanium composite thin films prepared using a multicomponent target pulsed laser deposition process. These materials were examined using transmission electron microscopy, Raman spectroscopy, nanoindentation, electrochemical charge transfer testing, and platelet adhesion testing. Cross-sectional transmission electron microscopy revealed that silver self-assembles into nanoparticle arrays within the diamondlike carbon matrix in the diamondlike carbon-silver composite film. On the other hand, titanium self-assembles into alternating nanometer-thick titanium carbide layers within the diamondlike carbon matrix in the diamondlike carbon-titanium composite film. The hemocompatibility of these materials was examined using electrochemical charge transfer testing and platelet adhesion testing. A few small, widely scattered crystals were observed on the surface of the unalloyed diamondlike carbon film exposed to platelet rich plasma. On the other hand, dense fibrin networks with densely aggregated platelets were observed on the surfaces of diamondlike carbon-silver and diamondlike carbon-titanium composite thin films exposed to platelet rich plasma. Electrochemical testing revealed that the time constant for the diamondlike carbon thin film (λ = 1) was significantly higher than those for the diamondlike carbon-silver and diamondlike carbon-titanium composite thin films. These results suggest possible uses for diamondlike carbon thin films and diamondlike carbon-metal composite thin films as coatings in next generation cardiovascular implants.

Original languageEnglish
Pages (from-to)1941-1948
Number of pages8
JournalDiamond and Related Materials
Volume15
Issue number11-12 SPEC. ISS.
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Composite films
Carbon
Metals
Thin films
composite materials
carbon
thin films
metals
Platelets
Titanium
Silver
platelets
Carbon films
titanium
silver
Testing
Charge transfer
Adhesion
Transmission electron microscopy
Plasmas

Keywords

  • Diamondlike carbon
  • Hemocompatibility
  • Pulsed laser deposition

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Andara, M., Agarwal, A., Scholvin, D., Gerhardt, R. A., Doraiswamy, A., Jin, C., ... Su, Y. Y. (2006). Hemocompatibility of diamondlike carbon-metal composite thin films. Diamond and Related Materials, 15(11-12 SPEC. ISS.), 1941-1948. https://doi.org/10.1016/j.diamond.2006.05.013

Hemocompatibility of diamondlike carbon-metal composite thin films. / Andara, Melanie; Agarwal, Arvind; Scholvin, Dirk; Gerhardt, Rosario A.; Doraiswamy, Anand; Jin, Chunming; Narayan, Roger J.; Shih, Chun C.; Shih, Chun Ming; Lin, Shing Jong; Su, Yea Yang.

In: Diamond and Related Materials, Vol. 15, No. 11-12 SPEC. ISS., 11.2006, p. 1941-1948.

Research output: Contribution to journalArticle

Andara, M, Agarwal, A, Scholvin, D, Gerhardt, RA, Doraiswamy, A, Jin, C, Narayan, RJ, Shih, CC, Shih, CM, Lin, SJ & Su, YY 2006, 'Hemocompatibility of diamondlike carbon-metal composite thin films', Diamond and Related Materials, vol. 15, no. 11-12 SPEC. ISS., pp. 1941-1948. https://doi.org/10.1016/j.diamond.2006.05.013
Andara M, Agarwal A, Scholvin D, Gerhardt RA, Doraiswamy A, Jin C et al. Hemocompatibility of diamondlike carbon-metal composite thin films. Diamond and Related Materials. 2006 Nov;15(11-12 SPEC. ISS.):1941-1948. https://doi.org/10.1016/j.diamond.2006.05.013
Andara, Melanie ; Agarwal, Arvind ; Scholvin, Dirk ; Gerhardt, Rosario A. ; Doraiswamy, Anand ; Jin, Chunming ; Narayan, Roger J. ; Shih, Chun C. ; Shih, Chun Ming ; Lin, Shing Jong ; Su, Yea Yang. / Hemocompatibility of diamondlike carbon-metal composite thin films. In: Diamond and Related Materials. 2006 ; Vol. 15, No. 11-12 SPEC. ISS. pp. 1941-1948.
@article{b2b756bb4cfc4578be0af3e68fc62b79,
title = "Hemocompatibility of diamondlike carbon-metal composite thin films",
abstract = "We have investigated the hemocompatibility of diamondlike carbon-silver composite and diamondlike carbon-titanium composite thin films prepared using a multicomponent target pulsed laser deposition process. These materials were examined using transmission electron microscopy, Raman spectroscopy, nanoindentation, electrochemical charge transfer testing, and platelet adhesion testing. Cross-sectional transmission electron microscopy revealed that silver self-assembles into nanoparticle arrays within the diamondlike carbon matrix in the diamondlike carbon-silver composite film. On the other hand, titanium self-assembles into alternating nanometer-thick titanium carbide layers within the diamondlike carbon matrix in the diamondlike carbon-titanium composite film. The hemocompatibility of these materials was examined using electrochemical charge transfer testing and platelet adhesion testing. A few small, widely scattered crystals were observed on the surface of the unalloyed diamondlike carbon film exposed to platelet rich plasma. On the other hand, dense fibrin networks with densely aggregated platelets were observed on the surfaces of diamondlike carbon-silver and diamondlike carbon-titanium composite thin films exposed to platelet rich plasma. Electrochemical testing revealed that the time constant for the diamondlike carbon thin film (λ = 1) was significantly higher than those for the diamondlike carbon-silver and diamondlike carbon-titanium composite thin films. These results suggest possible uses for diamondlike carbon thin films and diamondlike carbon-metal composite thin films as coatings in next generation cardiovascular implants.",
keywords = "Diamondlike carbon, Hemocompatibility, Pulsed laser deposition",
author = "Melanie Andara and Arvind Agarwal and Dirk Scholvin and Gerhardt, {Rosario A.} and Anand Doraiswamy and Chunming Jin and Narayan, {Roger J.} and Shih, {Chun C.} and Shih, {Chun Ming} and Lin, {Shing Jong} and Su, {Yea Yang}",
year = "2006",
month = "11",
doi = "10.1016/j.diamond.2006.05.013",
language = "English",
volume = "15",
pages = "1941--1948",
journal = "Diamond and Related Materials",
issn = "0925-9635",
publisher = "Elsevier BV",
number = "11-12 SPEC. ISS.",

}

TY - JOUR

T1 - Hemocompatibility of diamondlike carbon-metal composite thin films

AU - Andara, Melanie

AU - Agarwal, Arvind

AU - Scholvin, Dirk

AU - Gerhardt, Rosario A.

AU - Doraiswamy, Anand

AU - Jin, Chunming

AU - Narayan, Roger J.

AU - Shih, Chun C.

AU - Shih, Chun Ming

AU - Lin, Shing Jong

AU - Su, Yea Yang

PY - 2006/11

Y1 - 2006/11

N2 - We have investigated the hemocompatibility of diamondlike carbon-silver composite and diamondlike carbon-titanium composite thin films prepared using a multicomponent target pulsed laser deposition process. These materials were examined using transmission electron microscopy, Raman spectroscopy, nanoindentation, electrochemical charge transfer testing, and platelet adhesion testing. Cross-sectional transmission electron microscopy revealed that silver self-assembles into nanoparticle arrays within the diamondlike carbon matrix in the diamondlike carbon-silver composite film. On the other hand, titanium self-assembles into alternating nanometer-thick titanium carbide layers within the diamondlike carbon matrix in the diamondlike carbon-titanium composite film. The hemocompatibility of these materials was examined using electrochemical charge transfer testing and platelet adhesion testing. A few small, widely scattered crystals were observed on the surface of the unalloyed diamondlike carbon film exposed to platelet rich plasma. On the other hand, dense fibrin networks with densely aggregated platelets were observed on the surfaces of diamondlike carbon-silver and diamondlike carbon-titanium composite thin films exposed to platelet rich plasma. Electrochemical testing revealed that the time constant for the diamondlike carbon thin film (λ = 1) was significantly higher than those for the diamondlike carbon-silver and diamondlike carbon-titanium composite thin films. These results suggest possible uses for diamondlike carbon thin films and diamondlike carbon-metal composite thin films as coatings in next generation cardiovascular implants.

AB - We have investigated the hemocompatibility of diamondlike carbon-silver composite and diamondlike carbon-titanium composite thin films prepared using a multicomponent target pulsed laser deposition process. These materials were examined using transmission electron microscopy, Raman spectroscopy, nanoindentation, electrochemical charge transfer testing, and platelet adhesion testing. Cross-sectional transmission electron microscopy revealed that silver self-assembles into nanoparticle arrays within the diamondlike carbon matrix in the diamondlike carbon-silver composite film. On the other hand, titanium self-assembles into alternating nanometer-thick titanium carbide layers within the diamondlike carbon matrix in the diamondlike carbon-titanium composite film. The hemocompatibility of these materials was examined using electrochemical charge transfer testing and platelet adhesion testing. A few small, widely scattered crystals were observed on the surface of the unalloyed diamondlike carbon film exposed to platelet rich plasma. On the other hand, dense fibrin networks with densely aggregated platelets were observed on the surfaces of diamondlike carbon-silver and diamondlike carbon-titanium composite thin films exposed to platelet rich plasma. Electrochemical testing revealed that the time constant for the diamondlike carbon thin film (λ = 1) was significantly higher than those for the diamondlike carbon-silver and diamondlike carbon-titanium composite thin films. These results suggest possible uses for diamondlike carbon thin films and diamondlike carbon-metal composite thin films as coatings in next generation cardiovascular implants.

KW - Diamondlike carbon

KW - Hemocompatibility

KW - Pulsed laser deposition

UR - http://www.scopus.com/inward/record.url?scp=33751163493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751163493&partnerID=8YFLogxK

U2 - 10.1016/j.diamond.2006.05.013

DO - 10.1016/j.diamond.2006.05.013

M3 - Article

VL - 15

SP - 1941

EP - 1948

JO - Diamond and Related Materials

JF - Diamond and Related Materials

SN - 0925-9635

IS - 11-12 SPEC. ISS.

ER -