Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population

Ting An Lin, Ching Fen Yang, Yao Chung Liu, Jin Hwang Liu, Tzeon jye Chiou, Liang Tsai Hsiao, Hsiu Ju Yen, Chia Jen Liu, Hao Yuan Wang, Po Shen Ko, Sheng Hsuan Chien, Jyh Pyng Gau

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare form of cytotoxic T-cell lymphoma. It is believed that SPTL in patients without hemophagocytic syndrome (HPS) follows an indolent course; in contrast, SPTL in patients with HPS has been associated with unfavorable survival. To provide more clinical data on SPTL in Asian populations and to identify optimal therapeutic strategies for SPTL, we assessed the clinicopathological features and long-term follow-up data of 10 Taiwanese SPTL patients diagnosed at a single center. Our study demonstrates a group of patients with high incidence of HPS (50%), rather aggressive courses, and early progression. A total of eight patients underwent hematopoietic stem cell transplant (HSCT), including one autologous HSCT and seven allogeneic HSCT. Seven of eight patients receiving HSCT achieved durable remission and maintained in remission for over 30 months (range 30–132 months). There was no difference in 3-year survival of patients with HPS (80%) compared with patients without HPS (80%). Of long-term survivors in the HPS group, three of four received HSCT (autologous HSCT, n = 1; allogeneic HSCT, n = 2). Our study indicated that HSCT is a curative option for eligible SPTL patients with HPS.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalInternational Journal of Hematology
Volume109
Issue number2
DOIs
Publication statusPublished - Feb 20 2019
Externally publishedYes

Keywords

  • Allogeneic
  • Chemotherapy
  • Hemophagocytic syndrome
  • Stem cell transplantation
  • Subcutaneous panniculitis-like T-cell lymphoma

ASJC Scopus subject areas

  • Hematology

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