Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis

Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. Results: We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. Conclusion: Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition.

Original languageEnglish
Pages (from-to)736-741
Number of pages6
JournalJournal of the Formosan Medical Association
Volume114
Issue number8
DOIs
Publication statusPublished - Aug 1 2015
Externally publishedYes

Fingerprint

Mouth Diseases
Hematinics
Pernicious Anemia
Hemoglobins
Erythrocyte Indices
Homocysteine
Healthy Volunteers
Iron
Vitamin B 12 Deficiency
Vitamin B 12
Folic Acid
Serum

Keywords

  • Gastric parietal cell antibody
  • Hemoglobin
  • Macrocytosis
  • Mean corpuscular volume
  • Pernicious anemia
  • Vitamin B12

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. / Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Cheng, Shih Jung; Chen, Hsin Ming; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 114, No. 8, 01.08.2015, p. 736-741.

Research output: Contribution to journalArticle

Chang, Julia Yu Fong ; Wang, Yi Ping ; Wu, Yang Che ; Cheng, Shih Jung ; Chen, Hsin Ming ; Sun, Andy. / Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 8. pp. 736-741.
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abstract = "Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. Results: We found that 30 (50.0{\%}), 7 (11.7{\%}), 24 (40.0{\%}), and three (5.0{\%}) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3{\%}) and 16 (26.7{\%}) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7{\%} of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. Conclusion: Only 16.7{\%} of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition.",
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AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Chen, Hsin Ming

AU - Sun, Andy

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N2 - Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. Results: We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. Conclusion: Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition.

AB - Background/purpose: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. Results: We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. Conclusion: Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition.

KW - Gastric parietal cell antibody

KW - Hemoglobin

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KW - Mean corpuscular volume

KW - Pernicious anemia

KW - Vitamin B12

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