Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients

Chun Pin Chiang, Yu Hsueh Wu, Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Andy Sun

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs RAS/BD patients. Moreover, Abs RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs RAS/BD patients.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalJournal of the Formosan Medical Association
Volume118
Issue number1P2
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Gastric Parietal Cells
Hematinics
Hyperhomocysteinemia
Behcet Syndrome
Autoantibodies
Stomach
Thyroid Gland
Antibodies
Hemoglobins
Vitamin B 12 Deficiency
Iron
Healthy Volunteers
Homocysteine
Vitamin B 12
Serum
Folic Acid
Sutton disease 2
Anemia

Keywords

  • Anemia
  • Behcet's disease
  • Gastric parietal cell antibody
  • Hyperhomo-cysteinemia
  • Iron deficiency
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematinic deficiencies and hyperhomocysteinemia in gastric parietal cell antibody-positive or gastric and thyroid autoantibodies-negative Behcet's disease patients. / Chiang, Chun Pin; Wu, Yu Hsueh; Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 118, No. 1P2, 01.01.2019, p. 347-353.

Research output: Contribution to journalArticle

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abstract = "Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs − RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs − RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs − RAS/BD patients. Moreover, Abs − RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs − RAS/BD patients.",
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AU - Chiang, Chun Pin

AU - Wu, Yu Hsueh

AU - Chang, Julia Yu Fong

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Sun, Andy

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AB - Background/Purpose: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA + RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs − RAS/BD) patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA + RAS/BD patients, 41 Abs − RAS/BD patients, and 126 healthy control subjects. Results: GPCA + RAS/BD patients had significantly lower mean blood Hb (for men only), iron (for men only), and vitamin B12 levels as well as a significantly higher mean serum homocysteine level than 126 healthy control subjects. Moreover, GPCA + RAS/BD patients had significantly greater frequencies of blood Hb, iron, and vitamin B12 deficiencies and of hyperhomocysteinemia than healthy control subjects. GPCA + RAS/BD patients did have a significantly lower mean serum vitamin B12 level and a significantly higher mean serum homocysteine level as well as significantly greater frequencies of vitamin B12 deficiency and of hyperhomocysteinemia than Abs − RAS/BD patients. Moreover, Abs − RAS/BD patients did have significantly lower mean blood Hb, iron, and folic acid levels and significantly greater frequencies of blood Hb and iron deficiencies than healthy control subjects. Conclusion: The GPCA is a major factor causing vitamin B12 deficiency and hyperhomocyteinemia in GPCA + RAS/BD patients. RAS/BD itself does play a significant role in causing anemia and hematinic deficiencies in both GPCA + RAS/BD and Abs − RAS/BD patients.

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KW - Hyperhomo-cysteinemia

KW - Iron deficiency

KW - Vitamin B12 deficiency

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