Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis

Yang Che Wu, Yu Hsueh Wu, Yi Ping Wang, Julia Yu Fong Chang, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background/Purpose Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG−/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Results Both AG+/RAS and AG−/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG−/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5%) had normocytic anemia and 23 (33.3%) had iron deficiency anemia. Of 38 anemia AG−/RAS patients, 26 (68.4%) had normocytic anemia and 5 (13.2%) had iron deficiency anemia. Conclusion We conclude that some of AG+/RAS or AG−/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG−/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively.

Original languageEnglish
Pages (from-to)1061-1068
Number of pages8
JournalJournal of the Formosan Medical Association
Volume115
Issue number12
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

Fingerprint

Glossitis
Hematinics
Anemia
Hemoglobins
Iron
Iron-Deficiency Anemias
Sutton disease 2
Vitamin B 12

Keywords

  • Anemia
  • Atrophic glossitis
  • Hematinic deficiency
  • Iron
  • Recurrent aphthous stomatitis
  • Vitamin B12

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. / Wu, Yang Che; Wu, Yu Hsueh; Wang, Yi Ping; Chang, Julia Yu Fong; Chen, Hsin Ming; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 115, No. 12, 01.12.2016, p. 1061-1068.

Research output: Contribution to journalArticle

Wu, Yang Che ; Wu, Yu Hsueh ; Wang, Yi Ping ; Chang, Julia Yu Fong ; Chen, Hsin Ming ; Sun, Andy. / Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. In: Journal of the Formosan Medical Association. 2016 ; Vol. 115, No. 12. pp. 1061-1068.
@article{d6854750fa534d95a7ea289f1d7d2090,
title = "Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis",
abstract = "Background/Purpose Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG−/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Results Both AG+/RAS and AG−/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG−/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5{\%}) had normocytic anemia and 23 (33.3{\%}) had iron deficiency anemia. Of 38 anemia AG−/RAS patients, 26 (68.4{\%}) had normocytic anemia and 5 (13.2{\%}) had iron deficiency anemia. Conclusion We conclude that some of AG+/RAS or AG−/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG−/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively.",
keywords = "Anemia, Atrophic glossitis, Hematinic deficiency, Iron, Recurrent aphthous stomatitis, Vitamin B12",
author = "Wu, {Yang Che} and Wu, {Yu Hsueh} and Wang, {Yi Ping} and Chang, {Julia Yu Fong} and Chen, {Hsin Ming} and Andy Sun",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.jfma.2016.10.007",
language = "English",
volume = "115",
pages = "1061--1068",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "12",

}

TY - JOUR

T1 - Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis

AU - Wu, Yang Che

AU - Wu, Yu Hsueh

AU - Wang, Yi Ping

AU - Chang, Julia Yu Fong

AU - Chen, Hsin Ming

AU - Sun, Andy

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background/Purpose Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG−/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Results Both AG+/RAS and AG−/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG−/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5%) had normocytic anemia and 23 (33.3%) had iron deficiency anemia. Of 38 anemia AG−/RAS patients, 26 (68.4%) had normocytic anemia and 5 (13.2%) had iron deficiency anemia. Conclusion We conclude that some of AG+/RAS or AG−/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG−/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively.

AB - Background/Purpose Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG−/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Results Both AG+/RAS and AG−/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Moreover, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG−/RAS patients. Of 69 anemia AG+/RAS patients, 30 (43.5%) had normocytic anemia and 23 (33.3%) had iron deficiency anemia. Of 38 anemia AG−/RAS patients, 26 (68.4%) had normocytic anemia and 5 (13.2%) had iron deficiency anemia. Conclusion We conclude that some of AG+/RAS or AG−/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG−/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG−/RAS patients, respectively.

KW - Anemia

KW - Atrophic glossitis

KW - Hematinic deficiency

KW - Iron

KW - Recurrent aphthous stomatitis

KW - Vitamin B12

UR - http://www.scopus.com/inward/record.url?scp=85006265693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006265693&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2016.10.007

DO - 10.1016/j.jfma.2016.10.007

M3 - Article

VL - 115

SP - 1061

EP - 1068

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 12

ER -