Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency

Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background/Purpose: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods: The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B 12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) < 13. Results: We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion: In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.

Original languageEnglish
Pages (from-to)806-812
Number of pages7
JournalJournal of the Formosan Medical Association
Volume114
Issue number9
DOIs
Publication statusPublished - Sep 1 2015
Externally publishedYes

Fingerprint

Mouth Diseases
Folic Acid Deficiency
Hematinics
Anemia
Macrocytic Anemia
Hemoglobins
Erythrocyte Indices
Folic Acid
Iron
Gastric Parietal Cells
Vitamin B 12 Deficiency
Pernicious Anemia
Thalassemia
Iron-Deficiency Anemias
Vitamin B 12
Antibodies

Keywords

  • Folic acid
  • Macrocytic anemia
  • Microcytic anemia
  • Normocytic anemia
  • Pernicious anemia
  • Vitamin B

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. / Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Cheng, Shih Jung; Chen, Hsin Ming; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 114, No. 9, 01.09.2015, p. 806-812.

Research output: Contribution to journalArticle

Chang, Julia Yu Fong ; Wang, Yi Ping ; Wu, Yang Che ; Cheng, Shih Jung ; Chen, Hsin Ming ; Sun, Andy. / Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 9. pp. 806-812.
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abstract = "Background/Purpose: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods: The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B 12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) < 13. Results: We found that by WHO definitions, 73 (36.9{\%}), 41 (20.7{\%}), and 10 (5.1{\%}) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion: In addition to macrocytic anemia (2.0{\%}), FAD patients may have concomitant normocytic (23.7{\%}) or microcytic (11.1{\%}) anemia.",
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AU - Chang, Julia Yu Fong

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Chen, Hsin Ming

AU - Sun, Andy

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N2 - Background/Purpose: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods: The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B 12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) < 13. Results: We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion: In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.

AB - Background/Purpose: Folic acid deficiency (FAD) may result in macrocytic anemia. This study assessed the hematinic deficiencies and anemia statuses in oral mucosal disease patients with FAD (defined as folic acid ≤ 6 ng/mL). Methods: The blood hemoglobin (Hb), iron, vitamin B 12 , and folic acid concentrations, serum gastric parietal cell antibody level, and mean corpuscular volume (MCV) in 198 oral mucosal disease patients with FAD were measured. Based on World Health Organization (WHO) criteria, anemia or Hb deficiency was defined as having an Hb concentration of <13 g/dL for men and <12 g/dL for women. In this study, macrocytic anemia due to FAD was defined as having an MCV ≥100 fL and folic acid ≤6 ng/mL; pernicious anemia as having MCV ≥100 fL, vitamin B 12 < 200 pg/mL, and serum gastric parietal cell antibody positivity; iron deficiency anemia as having MCV <80 fL and iron <60 μg/dL; and thalassemia trait as having MCV <74 fL, red blood cell (RBC) count > 5.0 × 10 12 /L, and Mentzer index (MCV/RBC) < 13. Results: We found that by WHO definitions, 73 (36.9%), 41 (20.7%), and 10 (5.1%) of our 198 FAD patients had concomitant Hb, iron, and vitamin B 12 deficiencies, respectively. Of 73 anemic FAD patients, three had macrocytic anemia due to FAD, one had pernicious anemia, 14 had iron deficiency anemia, eight had thalassemia trait, and the resting 47 had normocytic anemia. Conclusion: In addition to macrocytic anemia (2.0%), FAD patients may have concomitant normocytic (23.7%) or microcytic (11.1%) anemia.

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KW - Normocytic anemia

KW - Pernicious anemia

KW - Vitamin B

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