Helicobacter pylori infection increases the risk of adult-onset asthma: a nationwide cohort study

Y. C. Wang, T. Y. Lin, S. T. Shang, H. J. Chen, C. H. Kao, C. C. Wu, T. Y. Yang

Research output: Contribution to journalArticle

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Abstract

Helicobacter pylori infection (HPI) appears to reduce risk of childhood-onset asthma, but the relationship between HPI and adult-onset asthma is inconclusive. This study explored the potential association between HPI and risk of adult-onset asthma. We conducted a national insurance retrospective cohort study using the longitudinal health insurance database (LHID 2000) in Taiwan. We enrolled the HPI group consisting of 1664 patients with HPI diagnosis between 2000 and 2007, and the non-HPI group consisting of 6,656 age- and sex-matched subjects without HPI. All study participants had been followed up from index date to the diagnostic date of asthma, withdrawal from the National Health Insurance program, or the end of 2011, which came first. We analyzed risk of adult-onset asthma with respect to sex, age, and comorbidities by using Cox models. Cigarette smoking status, which could not be obtained from the program, was adjusted indirectly by considering chronic obstructive pulmonary diseases in our statistical models because the disease is related to heavy smoking. After adjustment for sex, age, and comorbidities, HPI was significantly associated with an increased 1.38-fold risk of adult-onset asthma. Moreover, among people without comorbidities, the 1.85-fold risk of adult-onset asthma remained higher for the HPI population compared with the non-HPI population. In this study, patients with HPI exhibited a significantly higher risk of adult-onset asthma than did the subjects without HPI.

Original languageEnglish
Pages (from-to)1587-1594
Number of pages8
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 1 2017

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Helicobacter Infections
Helicobacter pylori
Cohort Studies
Asthma
Comorbidity
Pylorus
National Health Programs
Smoking
Statistical Models
Health Insurance
Infection
Insurance
Taiwan
Proportional Hazards Models
Chronic Obstructive Pulmonary Disease
Population
Retrospective Studies
Databases

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Helicobacter pylori infection increases the risk of adult-onset asthma : a nationwide cohort study. / Wang, Y. C.; Lin, T. Y.; Shang, S. T.; Chen, H. J.; Kao, C. H.; Wu, C. C.; Yang, T. Y.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 36, No. 9, 01.09.2017, p. 1587-1594.

Research output: Contribution to journalArticle

Wang, Y. C. ; Lin, T. Y. ; Shang, S. T. ; Chen, H. J. ; Kao, C. H. ; Wu, C. C. ; Yang, T. Y. / Helicobacter pylori infection increases the risk of adult-onset asthma : a nationwide cohort study. In: European Journal of Clinical Microbiology and Infectious Diseases. 2017 ; Vol. 36, No. 9. pp. 1587-1594.
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