Helicobacter pylori cagA, iceA and vacA genotypes in patients with gastric cancer in Taiwan

Hwai Jeng Lin, Chin Lin Perng, Wen Ching Lo, Chew Wun Wu, Guan Ying Tseng, Anna Fen Yau Li, I. Chen Sun, Yueh Hsing Ou

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26 Citations (Scopus)

Abstract

Aim: Helicobacter pylori (H pylori) has been linked to chronic gastritis, peptic ulcer, gastric cancer and MALT-lymphoma. The link of genotypes of H pylori to gastric cancer remains controversial. The aim of this study was to investigate the H pylori vacA alleles, cagA and iceA in patients with gastric cancer in Taiwan. Methods: Patients with gastric cancer, peptic ulcer and chronic gastritis were enrolled in this study. We obtained biopsy specimens from the stomach at least 2 cm away from the tumor margin in patients with gastric cancer, and from the antrum of stomach in patients with peptic ulcer or chronic gastritis. DNA extraction and polymerase chain reaction were used to detect the presence or absence of cagA and to assess the polymorphism of vacA and iceA. Results: A total of 168 patients (gastric ulcer: 77, duodenal ulcer: 66, and chronic gastritis: 25) were found to have positive PCR results of the biopsy specimens from patients with peptic ulcer and chronic gastritis. We found positive cagA (139/168, 83%), m2 (84/168, 50%) and iceA1 (125/168, 74%) strains in the majority of patients. In patients with gastric cancer, the vacA s1a and s1c subtypes were less commonly found than those in non-cancer patients (35/66 vs 127/168, P=0.0001 for s1a and 13/66 vs 93/168, P

Original languageEnglish
Pages (from-to)2493-2497
Number of pages5
JournalWorld Journal of Gastroenterology
Volume10
Issue number17
Publication statusPublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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